Maternal Thyroid Hormone Replacement Therapy Exposure and Language and Communication Skills of Offspring at 8 Years of Age

Frank, Anna-Simone; Lupattelli, Angela; Brandlistuen, Ragnhild Eek; Nordeng, Hedvig

doi:10.1001/jamanetworkopen.2019.12424

Cited by 5 publications

(3 citation statements)

References 45 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only one study by Frank et al 33 investigated language and speech impairment as the clinical outcome but null association was observed in the study (HR: 0.75, 95% CI: 0.38 -1.43, Table 3).…”

Section: Hypothyroidismmentioning

confidence: 93%

Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis

Leung

Man

et al. 2020

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Context Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring. Objective To review the association between maternal thyroid dysfunction and the risk of adverse outcomes in offspring. Data Sources PubMed, EMBASE and Cochrane Library. Study Selections Eligible studies reported the association between maternal thyroid hormone function and the risk of adverse outcomes in their children. Data Extraction Reviewers extracted data on study characteristics and results independently. Data Synthesis Estimates were pooled and reported as odds ratio (OR) with 95% confidence interval (CI). I2 tests were applied to assess the heterogeneity across studies. Results We identified 29 eligible articles and found an association between maternal hyperthyroidism and attention deficit hyperactivity disorder (ADHD) (OR: 1.18, 95% CI: 1.04 - 1.34, I2 = 0%) and epilepsy (OR: 1.19, 95% CI: 1.08 - 1.31, I2 = 0%) in offspring; as well as an association of maternal hypothyroidism with increased risk of ADHD (OR: 1.14, 95% CI: 1.03 - 1.26, I2 = 25%), autism spectrum disorder (OR: 1.41, 95% CI: 1.05 - 1.90, I2 = 63%) and epilepsy (OR: 1.21, 95% CI: 1.06 - 1.39, I2 = 0%) in offspring. Conclusion Routine measurement and timely treatment on thyroid function should be considered for pregnant women.

show abstract

Section: Hypothyroidismmentioning

confidence: 93%

Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis

Leung

Man

et al. 2020

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

“…Indeed, only 1% of the women who answered the week-30-questionnaire gave birth before week 33 of pregnancy, whereas 10% of the women who did not answer the questionnaire gave birth before week 33. This means that paper iii, and several other papers using MoBa data to study medication safety in pregnancy [210][211][212][213][214][215], have unintentionally conditioned on extremely preterm birth (birth before week 28 [216]), and maybe also very preterm birth (birth between week 28 and 32 [216]). The incidence of ADHD appears to increase with decreasing gestational age [217,218].…”

Section: Potential Unintended Consequences Of Inclusion Criteriamentioning

confidence: 99%

Prenatal exposure to nitrofurantoin and risk of childhood leukaemia: a registry-based cohort study in four Nordic countries

Hjorth

Pottegård

Broe

et al. 2021

International Journal of Epidemiology

Self Cite

View full text Add to dashboard Cite

Background Studies have suggested increased risks of childhood leukaemia after prenatal exposure to antibiotics, particularly nitrofurantoin. However, these findings may be related to the underlying maternal infection. This multinational study aimed to investigate the association between prenatal nitrofurantoin exposure and childhood leukaemia while accounting for maternal infection. Methods In a population-based cohort study of children born in Denmark, Finland, Norway or Sweden from 1997 to 2013, prenatal exposure to nitrofurantoin or pivmecillinam (active comparator) was ascertained from national Prescription Registries. Childhood leukaemia was identified by linkage to national Cancer Registries. Poisson regression was used to estimate incidence rate ratios (IRRs) and incidence rate differences (IRDs) with inverse probability of treatment weights applied to account for confounding. Results We included 44 091 children prenatally exposed to nitrofurantoin and 247 306 children prenatally exposed to pivmecillinam. The children were followed for 9.3 years on average (standard deviation 4.1). There were 161 cases of childhood leukaemia. The weighted IRR for prenatal nitrofurantoin exposure when compared with pivmecillinam was 1.34 (95% confidence interval 0.88, 2.06), corresponding to an IRD of 15 per million person-years. Higher point estimates were seen for first- and third-trimester exposure. There was no evidence of a dose–response relationship. Conclusions Prenatal exposure to nitrofurantoin was not substantially associated with childhood leukaemia, although a slightly elevated IRR with confidence intervals including the null was observed, corresponding to a small absolute risk. The lack of a dose–response relationship and a clear biological mechanism to explain the findings suggests against a causal association.

show abstract

“…31 The imputation procedure included covariates, and additional variables with predictive value (Supplementary Information). The implementation of multiple imputation and its analysis were adapted from Frank et al [32][33][34]…”

Section: Missing Datamentioning

confidence: 99%

Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study

Broek

Lupattelli

Frank

et al. 2020

Pharmacoepidemiology and Drug

Self Cite

View full text Add to dashboard Cite

Purpose: Limited research has focused on the association between prenatal thyroid hormone replacement therapy (THRT) and motor function, communication skills, and behavior in preschool children. Here, we estimated the association between THRT during pregnancy and the first trimester and these developmental outcomes.Methods: This study was based on the Norwegian Mother, Father, and Child Cohort Study (MoBa) and other national registries. We included mother-child pairs exposed to THRT during pregnancy (n = 663), after delivery (n = 728), or unexposed (n = 28 040).Exposure to THRT was defined according to filled prescriptions. Child outcomes, presented as T-score differences, were parent-reported using the Ages and Stages Questionnaire, Strengths and Difficulties Questionnaire, and Child Behavior Checklist.Results: Of 29 431 mother-child pairs, 2.3% were prenatally exposed to THRT. We found no difference between prenatally exposed and unexposed children in regards to gross motor function (β: 0.17, 95% CI −1.19, 1.54), fine motor function (β: −0.17, 95%

show abstract

Maternal Thyroid Hormone Replacement Therapy Exposure and Language and Communication Skills of Offspring at 8 Years of Age

Cited by 5 publications

References 45 publications

Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis

Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis

Prenatal exposure to nitrofurantoin and risk of childhood leukaemia: a registry-based cohort study in four Nordic countries

Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study

Contact Info

Product

Resources

About