Maternal-to-Fetal Transfer of Ritodrine in Twin Pregnancy

Soma, Mayuko; Konda, Ainari; Yoshida, Hiroshi; Kishimoto, Seiji; Fukushima, Shoji; Toda, Takaki; Sasaki, Yōichi; Hayakawa, Tõru; Inotsume, Nobuo

doi:10.3999/jscpt.43.339

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, ritodrine passes through the placenta, where it may cause the development of tachycardia, hypoglycemia and intestinal paralysis in neonates 10,11) . We previously found essentially equal maternal-to-fetal ritodrine transfer in 14 women with twin pregnancies who were treated with continuous intravenous ritodrine 13) . Therefore, fetal development and adverse effects should be considered cautiously when increasing the dose of ritodrine.…”

Section: Discussionmentioning

confidence: 96%

Difference in Ritodrine Pharmacokinetics between Singleton and Twin Pregnancies

Soma

Konda

Fujieda

et al. 2013

Jpn. J. Clin. Pharmacol. Ther.

Self Cite

View full text Add to dashboard Cite

Aim : To determine the pharmacokinetics of ritodrine in singleton and twin pregnancies. Methods : We treated 105 pregnant women(with singletons, n＝67 ; with twins, n＝38)with continuous infusion of ritodrine and then measured steady-state serum ritodrine concentrations using HPLC. Results : Ritodrine clearance(mean±SD)was significantly lower in women who delivered twins than in those who delivered singletons(1.59±0.30 vs. 1.75±0.43 L／h／kg ; p＜0.001). Serum ritodrine concentration did not differ significantly between women who delivered preterm singletons and those who delivered preterm twins (97.5±61.1 vs. 89.6±50.4 ng／mL ; p＝NS), but was significantly higher in women who delivered twins at term than in those who delivered singletons at term(85.8±39.7 vs. 65.7±38.7 ng／mL ; p＜0.001). Conclusion : Ritodrine clearance was lower in twin pregnancies than in singleton pregnancies. The dose of ritodrine administered to maintain pregnancy should be controlled taking into account singleton or twin pregnancy. (Jpn J Clin Pharmacol Ther 2013 ; 44(5) : 389-394)

show abstract

Section: Discussionmentioning

confidence: 96%

Difference in Ritodrine Pharmacokinetics between Singleton and Twin Pregnancies

Soma

Konda

Fujieda

et al. 2013

Jpn. J. Clin. Pharmacol. Ther.

Self Cite

View full text Add to dashboard Cite

show abstract

<b>Elimination of Ritodrine in Mothers Pregnant with </b><b>Twins and Their Neonatal Twins </b>

Fujieda

Keira

Soma

et al. 2017

Jpn. J. Clin. Pharmacol. Ther.

Self Cite

View full text Add to dashboard Cite

This study aimed to clarify the individual elimination kinetics of serum ritodrine in women pregnant with twins and their twin neonates. Serum ritodrine concentrations in 10 twin pregnant women and their twin neonates were measured by liquid chromatography-tandem mass spectrometry(LC-MS／MS)using 100 mL of serum. The ritodrine elimination half-life in mothers was 5.0±2.2 (3.7-11.1) h［mean±SD (range)], while the halflives of ritodrine in the first and second newborns were 9.0± 8.4(4.2-29.6)and 7.2±4.3(4.3-13.2)h, respectively. Large individual differences in the half-life of ritodrine were observed in both mothers and their newborns. Since ritodrine remained in newborn serum for 24-48 h after birth, newborns need to be carefully monitored for ritodrine-related complications during this period.

show abstract

Maternal-to-Fetal Transfer of Ritodrine in Twin Pregnancy

Cited by 2 publications

References 16 publications

Difference in Ritodrine Pharmacokinetics between Singleton and Twin Pregnancies

Difference in Ritodrine Pharmacokinetics between Singleton and Twin Pregnancies

<b>Elimination of Ritodrine in Mothers Pregnant with </b><b>Twins and Their Neonatal Twins </b>

Contact Info

Product

Resources

About