Maternal transmission risk and antibody levels against hepatitis B virus e antigen in pregnant women

Abstract

The presence of maternal anti-HBe is protective against HBV MTCT, independent of the maternal serum HBV viral load.

Maternal viral load and hepatitis B virus mother‐to‐child transmission risk: A systematic review and meta‐analysis

“…We identified 346 unique papers after searching PubMed and Web of Science. Of these, 21 publications with 10 142 mother–child pairs were eligible for the evaluation of the relationship of maternal viral load and HBV MTCT risk. Figure shows the stages in identifying studies for inclusion in the review.…”

Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis

“…Similarly, high maternal viral load at the time of delivery was correlated with VT 11,12,15,16,26,28. Several studies quantified viral loads above which there was increased risk, but the results ranged from 10 5 –10 8 copies/mL 1,15,16,19,26,28,29.…”

“…Several studies quantified viral loads above which there was increased risk, but the results ranged from 10 5 –10 8 copies/mL 1,15,16,19,26,28,29. Gentile et al 1.…”

A decision analytic model for prevention of hepatitis B virus infection in Sub‐Saharan Africa using birth‐dose vaccination

“…1 Vertical (mother-to-child) transmission of HBV occurs via exposure to infected blood and body fluids during delivery, and is strongly associated with the maternal viral load (measured as the concentration of HBV DNA) and the presence of the HBV e antigen. 2 As the likelihood of chronic HBV infection is inversely related to age at the time of exposure, it is crucial that steps are taken to prevent vertical transmission.…”