Maternal treatment with dexamethasone during lactation delays male puberty and disrupts reproductive functions via hypothalamic–pituitary–gonadal axis alterations

Jeje, Sikirullai Olatunde; Akindele, O.O.; Balogun, Morufu E.; Raji, Yinusa

doi:10.1016/j.pathophys.2015.12.002

Cited by 6 publications

(12 citation statements)

References 27 publications

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“…Testicular cell alterations were very obvious in the DEX control group such as disorganisation of the seminiferous tubules, atrophy and vacuolisation in the seminiferous tubules, which were in accordance with Jeje et al. (). Histopathological alterations of seminiferous tubules cause the disruption of Sertoli and germ cells, which led to impaired spermatogenesis and germ cell loss.…”

Section: Discussionsupporting

confidence: 89%

“…In the present investigation, DEX caused dramatic alterations in the histological structure of testes and a marked decline in the level of testosterone, and these results were in harmony with previous reports for DEX‐induced animals (Gao et al., , & Ing et al., ). These disturbances may be due to the inhibition of gonadotropin secretion, excessive oxidative stress and the degeneration of Leydig cells (Chen, Wang, Wang, Gao, & Zhang, ; Jeje, Akindele, Balogun, & Raji, ; Yun, Ji‐Yeon, & Myoung, ).…”

Section: Discussionmentioning

confidence: 99%

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Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

Hasona

2018

Andrologia

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This study scrutinised the ameliorative properties of grape seed extract (GSE) in dexamethasone (DEX)-induced testicular and thyroid dysfunction associated with oxidative stress in male albino rats. Thirty-two healthy adult male albino rats were divided into four groups of eight animals each: normal, DEX control, DEX + GSE (200 mg/kg body weight) group and DEX + GSE (400 mg/kg body weight) group. The body weight gain and testes weight were assessed. Plasma testosterone and thyroid profile were determined. Testicular glucose-6-phosphate dehydrogenase (G-6-PDH), acid phosphatase (ACP), total protein and glutathione (GSH) levels, as well as catalase (CAT) activity also histopathological changes of the testis were evaluated. DEX treatment caused a significant decrease in body weight gain and weight of testes. Significant alterations in enzymatic and nonenzymatic antioxidants were observed. Moreover, a marked reduction in plasma testosterone levels and thyroid profile was observed. The administration of GSE significantly attenuated the deleterious effects of oxidative stress induced by DEX, as well as attenuated DEX-induced testicular and thyroid damage. Furthermore, DEX induced histological alterations in the testis. GSE ameliorated the injurious effects of DEX and improved the histological alterations in the testis.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

Hasona

2018

Andrologia

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“…This was in accordance with previous reports that early life dexamethasone exposure negatively affects somatic growth (Wang et al, 2010). Similarly, Jeje et al (2016) reported that maternal treatment with dexamethasone during the first two weeks of postnatal life and throughout lactation significantly reduced body weight of offspring at puberty. It was suggested that retardation of body weight may be linked to increased corticosterone level in offspring of dams treated with dexamethasone during lactation.…”

Section: Discussionsupporting

confidence: 93%

“…Epidemiological reports in humans and experimental results from laboratory animals show that adverse intrauterine and early postnatal life conditions alter adult phenotypes and predispose the exposed individuals to lifelong development of cardiovascular, metabolic and reproductive disorders (Drake et al, 2005(Drake et al, , 2007Jeje et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Dexamethasone is a common synthetic glucocorticoid drug with about 25 folds more glucocorticoid activity than endogenous cortisol produced by the adrenal glands (Tegethoff et al, 2009). Reports have shown that in rodents and other mammals including non-human primates, glucocorticoid overexposure resulting from maternal stress, impaired activity of 11βHSD-2 or treatment with dexamehasone during lactation may reduce growth rate and affect the development of reproductive structures (Jeje et al, 2016). It has been suggested that maternal treatment with dexamethasone during lactation may increase the susceptibility of testicular and epididymal tissues to oxidative stress (Jeje et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Allium cepa Linn juice protect against alterations in reproductive functions induced by maternal dexamethsone treatment during lactation in male offspring of Wistar rats

Jeje

Adegbite

Akindele

et al. 2020

Heliyon

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Treatment with dams with dexamethasone during lactation has been reported to induce oxidative stress in the testis of the offspring. Allium cepa L (Red Onion) is known to be a potent free radical scavenger. The protective role of Allium cepa against oxidative stress induced in testis following treatment with dexamehasone during lactation in Wistar rats was assessed. Twenty female rats were assigned into four groups (n ¼ 5) during lactation and they were treated as follows: Group 1 serve as Control (distilled water), Group 2, 3, and four were admistered dexamethasone (60 μg/kg), Allium cepa (5 ml/kg) and dexamethasone þ Allium cepa respectively. Testicular descent, pubertal age, sperm quality indices, and serum hormonal profile were assessed as indices of reproductive function. Testicular malondialdehyde (MDA) reduced glutathione (GSH) as well as superoxide dismutase (SOD) and catalase activities were assessed as measures of oxidative stress. Results obtained showed that dexamethasone caused significant (P < 0.05) reduction in testes weights, indices of sperm quality, serum testosterone, FSH, LH levels and testicular antioxidant enzyme activities. There was significant delay (P < 0.05) in days of testes descent, preputial separation and increase in testicular MDA. However, maternal treatment with Allium cepa Linn juice significantly (P < 0.05) improved both indices of reproductive function and testicular antioxidant enzymes. These findings suggest that Allium cepa Linn has a protective effect against testicular oxidative stress and reproductive dysfunction following treatment of dams with dexamethasone during lactation.

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Protective role of Allium cepa Linn (onion) juice on maternal dexamethasone induced alterations in reproductive functions of female offspring of Wistar rats

Jeje

Akpan

Kunle-Alabi

et al. 2021

Current Research in Physiology

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Maternal treatment with dexamethasone induces oxidative stress in the reproductive structures of offspring. Consumption of Allium cepa Linn improves antioxidant status. This study was designed to evaluate the protective role of Allium cepa Linn juice on maternal dexamethasone induced alterations in reproductive functions of the female offspring of Wistar rats. Twenty lactating dams (180–200 g) were randomly assigned into four groups (n = 5) on the day of parturition and treated as follows during lactation for 21 days: Control (5 ml/kg BW distilled water); Dexamethasone (60 μg/kg BW); Allium cepa (5 ml/kg BW); Dexamethasone + Allium cepa (60 μg/kg BW + 5 ml/kg BW). The female offspring were separated at birth. Days of vaginal opening and first oestrus cycle, length and frequency of estrous cycle as well as serum hormonal profiles were assessed as measure of reproductive functions. Ovarian superoxide dismutase (SOD) activity, catalase activity and malondialdehyde (MDA) level were measured as indices of oxidative stress. Oestrous cycle length, frequencies of diestrus as well as the Ovarian MDA were significantly increased (p < 0.05) in dexamethasone (DEX) group relative to control group. Serum 17β-oestradiol and corticosterone level in addition to SOD and catalase activities were significantly reduced (p < 0.05) in DEX group relative to control. Co-administration of Dex with Allium cepa Linn juice reduced the oestrous length, frequency of diestrous as well as ovarian MDA. There was also a significant increase in serum 17β-oestradiol, ovarian SOD and catalase activity. The results suggest that Allium cepa could protect against alterations in reproductive functions of offspring induced by maternal treatment with dexamethasone during lactation in Wistar rats. The flavonoid constituent of onion may also help in reducing oxidative stress in the offspring.

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Maternal treatment with dexamethasone during lactation delays male puberty and disrupts reproductive functions via hypothalamic–pituitary–gonadal axis alterations

Cited by 6 publications

References 27 publications

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

Allium cepa Linn juice protect against alterations in reproductive functions induced by maternal dexamethsone treatment during lactation in male offspring of Wistar rats

Protective role of Allium cepa Linn (onion) juice on maternal dexamethasone induced alterations in reproductive functions of female offspring of Wistar rats

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