Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress

Schroeder, Rachel; Nguyen, Lynn; Pieper, Andrew A.; Stevens, Hanna E.

doi:10.1016/j.bbr.2021.113558

Cited by 6 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wallker et al discovered that the P7C3 compounds play a role in antidepressant efficacy in mice via enhancing hippocampal neurogenesis [43]. In addition, they also discovered that P7C3-A20 contributed to the treatment of post-traumatic stress associated depression and anxiety, as well as prenatal maternal stress [44][45][46]. In preclinical models of peripheral neuropathy caused by chemotherapy and Alzheimer's disease, P7C3 could reverse the progress of neurological dysfunction and nerve cell death [36,47,48].…”

Section: Discussionmentioning

confidence: 99%

Higher concentration of P7C3 than required for neuroprotection suppresses renal cell carcinoma growth and metastasis

Shu,

Chen,

Huang

et al. 2024

J. Cancer

View full text Add to dashboard Cite

Background: P7C3 is a novel compound that has been widely applied in neurodegenerative diseases and nerve injury repair. Here, we show that higher concentrations of P7C3 than are required for in vivo neuroprotection have the novel function of suppressing renal cell carcinoma (RCC) proliferation and metastasis. Methods: Colony formation, CCK-8 and EdU assay were applied to evaluate RCC cell proliferation. Wound healing and transwell assay were used to measure RCC cell migration and invasion. Flow cytometry assay was employed to detect RCC cell apoptosis and cell cycle. qRT-PCR assay was carried out to measure ribonucleotide reductase subunit M2 (RRM2) mRNA expression level, while western blot assay was utilized to detect the expression level of target proteins. RCC cell growth in vivo was determined by xenografts in mice. Results: We observed that high concentrations of P7C3 could restrain the proliferation and metastasis of RCC cells and promote cell apoptosis. Mechanistically, this new effect of higher dose of P7C3 was associated with reduced expression of RRM2, and the beneficial efficacy of P7C3 in RCC was blocked when suppression of RRM2 was prevented. When RRM2 suppression was permitted, the cGAS-STING pathway was activated by virtue of RRM2/Bcl-2/Bax signaling. Lastly, intraperitoneal injection of this high level of P7C3 in mice potently inhibited tumor growth. Conclusion: In conclusion, we show here that P7C3 that exerts an anti-cancer effect in RCC. Our study indicated that P7C3 might act as a novel drug for RCC in the future. The regulatory signal pathway RRM2/Bcl-2/BAX/cGAS-STING might present novel insight to the potential mechanism of RCC development.

show abstract

Section: Discussionmentioning

confidence: 99%

Higher concentration of P7C3 than required for neuroprotection suppresses renal cell carcinoma growth and metastasis

Shu,

Chen,

Huang

et al. 2024

J. Cancer

View full text Add to dashboard Cite

show abstract

“…Schroeder and colleagues document dysregulation of NAD + generation in the brains of chronic prenatally stressed mice, with NAD + therapy preventing axonal degeneration, cognitive and depressive outcomes (220). The same NAD + stabilising therapy counters aberrant maternal care behaviours arising with chronic gestational stress (221).…”

Section: Differing Pyrimidine Nucleotide Metabolism and Sirtuin Signa...mentioning

confidence: 99%

The sex-dependent response to psychosocial stress and ischaemic heart disease

Helman

Headrick

Stapelberg

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Stress is an important risk factor for modern chronic diseases, with distinct influences in males and females. The sex specificity of the mammalian stress response contributes to the sex-dependent development and impacts of coronary artery disease (CAD). Compared to men, women appear to have greater susceptibility to chronic forms of psychosocial stress, extending beyond an increased incidence of mood disorders to include a 2- to 4-fold higher risk of stress-dependent myocardial infarction in women, and up to 10-fold higher risk of Takotsubo syndrome—a stress-dependent coronary-myocardial disorder most prevalent in post-menopausal women. Sex differences arise at all levels of the stress response: from initial perception of stress to behavioural, cognitive, and affective responses and longer-term disease outcomes. These fundamental differences involve interactions between chromosomal and gonadal determinants, (mal)adaptive epigenetic modulation across the lifespan (particularly in early life), and the extrinsic influences of socio-cultural, economic, and environmental factors. Pre-clinical investigations of biological mechanisms support distinct early life programming and a heightened corticolimbic-noradrenaline-neuroinflammatory reactivity in females vs. males, among implicated determinants of the chronic stress response. Unravelling the intrinsic molecular, cellular and systems biological basis of these differences, and their interactions with external lifestyle/socio-cultural determinants, can guide preventative and therapeutic strategies to better target coronary heart disease in a tailored sex-specific manner.

show abstract

Anti-inflammatory Therapy Protects Spiral Ganglion Neurons After Aminoglycoside Antibiotic-Induced Hair Cell Loss

et al. 2023

View full text Add to dashboard Cite

Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress

Cited by 6 publications

References 33 publications

Higher concentration of P7C3 than required for neuroprotection suppresses renal cell carcinoma growth and metastasis

Higher concentration of P7C3 than required for neuroprotection suppresses renal cell carcinoma growth and metastasis

The sex-dependent response to psychosocial stress and ischaemic heart disease

Anti-inflammatory Therapy Protects Spiral Ganglion Neurons After Aminoglycoside Antibiotic-Induced Hair Cell Loss

Contact Info

Product

Resources

About