Maternal urinary tract infection during pregnancy and long-term infectious morbidity of the offspring

Cohen, R.; Gutvirtz, Gil; Wainstock, Tamar

doi:10.1016/j.earlhumdev.2019.07.002

Cited by 29 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, one recent study of pregnant women with symptomatic UTI showed increased otorhinolaryngological and respiratory infections in offspring. 18 It is therefore plausible to suggest that bacteriuria by itself, with or without symptoms, is associated with respiratory infections in early life.…”

Section: Discussionmentioning

confidence: 99%

The significance of maternal asymptomatic bacteriuria during pregnancy on long-term offspring infectious hospitalizations

Nae

Wainstock

2021

J Dev Orig Health Dis

Self Cite

View full text Add to dashboard Cite

Asymptomatic bacteriuria (ASB) is a well-acknowledged infectious entity during pregnancy; yet its long-term implications are not well investigated. The present study aimed to test the association between maternal ASB during pregnancy and long-term offspring infectious hospitalizations. A population-based cohort analysis was conducted, comparing the incidence of long-term infectious-related hospitalizations of offspring born to mothers who were diagnosed with ASB during pregnancy, and those who did not have ASB. The study was conducted at a tertiary medical center and included all singleton deliveries between the years 1991 and 2014. Infectious morbidities were based on a predefined set of International Classification of Disease-9 codes. A Kaplan−Meier survival curve compared cumulative infectious hospitalization incidence between the groups, and a Cox regression model was used to adjust for confounding variables. During the study period, 212,984 deliveries met inclusion criteria. Of them, 5378 (2.5%) were diagnosed with ASB. As compared to offspring of non-ASB mothers, total long-term infectious hospitalizations were significantly higher among children to mothers who were diagnosed with ASB (13.1% vs. 11.1%, OR = 1.2, 95% CI 1.11–1.30, P ≤ 0.001). Likewise, a Kaplan−Meier curve demonstrated higher cumulative incidence of infectious hospitalizations among children born to mothers with ASB (log rank, P = 0.006). In the Cox regression model, while controlling for maternal age, diabetes mellitus, ethnicity, hypertensive disorders, and gestational age, maternal ASB was noted as an independent risk factor for long-term infectious morbidity in the offspring (adjusted HR = 1.1, 95% CI 1.01–1.17, P = 0.042). ASB during pregnancy increases offspring susceptibility to long-term infectious hospitalizations.

show abstract

Section: Discussionmentioning

confidence: 99%

The significance of maternal asymptomatic bacteriuria during pregnancy on long-term offspring infectious hospitalizations

Nae

Wainstock

2021

J Dev Orig Health Dis

Self Cite

View full text Add to dashboard Cite

show abstract

“…In contrast, other studies showed increased risk of short and long-term infectious morbidity in children born to mothers with an augmented inflammatory state during pregnancy. Preterm birth, maternal urinary tract infection, maternal obesity and maternal substance abuse were all demonstrated to be associated with increased infectious morbidity of the offspring [30][31][32][33][34][35]. We hypothesized that maternal tuberculosis can also promote an intrauterine environment that may alter immune responses of the offspring in his future.…”

Section: Long-term Outcomes Of Offspring Born To Women With Tuberculosismentioning

confidence: 99%

Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis

Sade

Wainstock

Pariente

2020

JCM

Self Cite

View full text Add to dashboard Cite

Objective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring. Study design: Perinatal outcome and long-term infectious morbidity of offspring of mothers with and without tuberculosis were assessed. The study groups were followed until 18 years of age tracking infectious-related morbidity and infectious-related hospitalizations and then compared. For perinatal outcome, generalized estimation equation models were used. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term infectious morbidity. A Cox proportional hazards model was conducted to control for confounders. Results: During the study period, 243,682 deliveries were included, of which 46 (0.018%) occurred in women with tuberculosis. Maternal tuberculosis was found to be independently associated with placental abruption, cesarean deliveries, and very low birth weight. However, offspring born to mothers with tuberculosis did not demonstrate higher rates of infectious-related morbidity. Maternal tuberculosis was not noted as an independent risk factor for long-term infectious morbidity of the offspring. Conclusion: In our study, maternal tuberculosis was found to be independently associated with adverse perinatal outcomes. However, higher risk for long-term infectious morbidity of the offspring was not demonstrated. Careful surveillance of these women is required.

show abstract

“…Evidence suggests that while some microorganisms such as Chlamydia trachomatis (Hughes & Field, 2015) may not necessarily cause any symptoms, nevertheless, they may have detrimental effects on fertility and pregnancy (Lundy et al, 2020; Solomon & Henkel, 2017). Furthermore, changes in the microbiome of the male reproductive tract are associated with poor fertilization and embryo development (Montagut et al, 1991), negative outcomes for ART (Ricci et al, 2018; Zeyad et al, 2018), complications during pregnancy and birth (Kalinderi et al, 2018) as well as recurrent miscarriage and adverse perinatal outcomes (Cohen et al, 2019; Howley et al, 2018). Bacterial microorganisms and the host inflammatory reaction trigger an overwhelming release of ROS in the local environment (Agarwal et al, 2018; Micheli et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The relationship between genitourinary microorganisms and oxidative stress, sperm DNA fragmentation and semen parameters in infertile men

Vaughan-Constable

Ramsay

et al. 2021

Andrologia

View full text Add to dashboard Cite

An imbalance in the genitourinary microbiome is emerging as a contributing factor to male infertility. The purpose of this study was to determine whether there is an association between genitourinary microorganisms and seminal oxidative stress, sperm DNA fragmentation and semen parameters. It included 770 men attending for diagnostic testing for subfertility. Genitourinary microorganisms were identified in 43.0% men; 20.1% had microorganisms in semen; 18.7% in urine; and 5.8% had microorganisms in urine and semen. Enterococcus faecalis was the most prevalent organism in semen (22.0% samples; 61.5% organisms) with Ureaplasma spp. (16.9% samples; 53.3% organisms) and Gardnerella vaginalis (11.4% samples; 37.4% organisms) most prevalent in urine. Semen parameters were unaffected by microorganisms (p > 0.05). Seminal ROS were significantly higher in men with microorganisms compared to those without (p < 0.001), particularly when present in both urine and semen (p < 0.01). Microorganisms were associated with significantly higher DNA fragmentation, irrespective of whether they were in semen or urine (p < 0.001). An imbalance in the genitourinary microbiome is associated with DNA damage and oxidative stress which may have considerable consequences for achieving an ongoing pregnancy. This highlights the need for incorporating genitourinary microorganism screening for all men as part of diagnostic evaluation prior to undergoing treatment for infertility.

show abstract

Maternal urinary tract infection during pregnancy and long-term infectious morbidity of the offspring

Cited by 29 publications

References 29 publications

The significance of maternal asymptomatic bacteriuria during pregnancy on long-term offspring infectious hospitalizations

The significance of maternal asymptomatic bacteriuria during pregnancy on long-term offspring infectious hospitalizations

Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis

The relationship between genitourinary microorganisms and oxidative stress, sperm DNA fragmentation and semen parameters in infertile men

Contact Info

Product

Resources

About