Maternal Urinary Tract Infection: Is It Associated With Neonatal Urinary Tract Infection?

Abstract

Objective: Maternal urinary tract infection is associated with intrauterine growth restriction, preterm delivery and low birth weight. The purpose of this study was to evaluate whether maternal urinary tract infection is related to neonatal urinary tract infection.
 Materials and methods: The present prospective study included 230 singleton neonates. The participants were divided into two groups based on in utero exposure to maternal urinary tract infections. The study group (exposure to maternal urinary tract infection) included 115 neonates and the control group (without exposure to maternal urinary tract infection) included 115 healthy neonates. Physical examination, urinalysis, urine culture and urinary system ultrasonography were carried out for all neonates.
 Results: There were 153 deliveries by cesarean section and 77 vaginal births. There was no statistically significant difference between the groups in terms of gender distribution, maternal age, birth weight, mode of delivery, gravida and gestational age. Although the difference was not significant, the incidence of low birth weight and preterm delivery were higher in the study group in comparison to that in the control group. There was a statistically significant higher rate of neonatal urinary tract infection in the study group compared with control group (25.2% vs. 7.8%, p<0.001). The most commonly discovered pathogens were Escherichia coli, followed by Klebsiella spp., Proteus spp., and Serratia spp. in the study group.
 Conclusion: The results of this study showed that the presence of maternal urinary tract infection may contribute to increased urinary tract infection frequency in the neonatal period. Neonates at risk for a urinary tract infection should be regularly monitored due to nonspecific clinical presentation.

D-dimer as a Useful Biomarker in Early Diagnosis of Neonatal Sepsis: A Single-Center Study From Romania

“…Regarding maternal urinary tract infection during pregnancy, Bilgin et al observed that the presence of maternal urinary tract infection may lead to an increase in urinary tract infection frequency in the newborn [ 29 ]. Furthermore, it is worth noting that urinary tract infection frequently leads to sepsis in neonates [ 30 ].…”

As consequências da infecção do trato urinário durante o período gestacional

“…Ademais, ocorreram taxas estatisticamente mais elevadas de infecção do trato urinário neonatal no grupo de prole exposta à ITU materna em comparação aos neonatos não expostos. Por conseguinte, observaram a presença mais comum dos patógenos Escherichia coli, Klebsiella spp., Proteus spp., e Serratia spp., de forma semelhante aos principais uropatógenos relacionados à ITU materna (BILGIN H, et al, 2021).…”

Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis

“…[ 106 ] Although the mechanism for the relationship is not clear, the prevalence of neonatal urinary tract infections in those born to mothers with a corresponding urinary infection is relatively increased. [ 107 , 108 ] Data from LMIC suggest that neonates born to mothers who experienced urinary tract infections during pregnancy are 3.55 times more likely to develop neonatal sepsis when compared to those born to mothers without a urinary tract infection. [ 109 ] It is plausible that untreated ascending urinary infections in pregnancy that lead to sepsis may result in fetoplacental transmission through hematogenous spread to infect the neonate.…”