1999
DOI: 10.1002/(sici)1097-0223(199910)19:10<918::aid-pd680>3.0.co;2-4
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Maternal urine hyperglycosylated hCG in pregnancies with Down syndrome

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Cited by 21 publications
(13 citation statements)
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“…An initial 1999 study reported an 80% detection rate (at a 5% false-positive rate) for second-trimester urine ITA measurements (8 ). A second study in 1999 found a lower detection rate of 45% at 14 weeks of gestation and later (9 ). Urine ITA was also analyzed as part of the Serum, Urine, and Ultrasound Screening Study (SURUSS) in 2003 and was reported to detect 40% of second-trimester Down syndrome pregnan-cies (10 ).…”
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confidence: 94%
“…An initial 1999 study reported an 80% detection rate (at a 5% false-positive rate) for second-trimester urine ITA measurements (8 ). A second study in 1999 found a lower detection rate of 45% at 14 weeks of gestation and later (9 ). Urine ITA was also analyzed as part of the Serum, Urine, and Ultrasound Screening Study (SURUSS) in 2003 and was reported to detect 40% of second-trimester Down syndrome pregnan-cies (10 ).…”
mentioning
confidence: 94%
“…Seventy-nine percent of cases were above the 95th centile of unaffected pregnancies. A subsequent case-control study of ITA using 45 Down syndrome pregnancies at 10 -19 weeks of gestation found a less increased median of 3.63 MoM (13 ). However, if the analysis was restricted to the 38 cases at 14 weeks and later, the median MoM increased to 4.64, and 45% of cases were above the 95th centile of unaffected pregnancies (5.2 MoM).…”
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confidence: 53%
“…At a 5% falsepositive rate, the predicted univariate Down syndrome detection rate for urinary ITA is 59% (approximate 95% confidence interval, 39 -78%) compared with estimates from the literature of 25%, 38%, 39%, and 46% for AFP, hCG, uE3, and DIA, respectively (2,20 ). This rate is lower than the 79% reported in an earlier study (7 ), but higher than the 40 -45% reported in others (13,14 ).…”
Section: Discussionmentioning
confidence: 99%
“…Even better results might have been obtained in both studies with fresh samples. Cuckle et al (1999), measured H-hCG in variously stored urine samples. H-hCG concentrations were less strikingly elevated in Down syndrome pregnancies in the second trimester.…”
Section: Discussionmentioning
confidence: 99%
“…Urine H-hCG measurements are very promising as a new high-sensitivity screening test for maternal Down syndrome. Cuckle et al (1999) carried out a case control study on H-hCG in Down syndrome pregnancies. However, the study was conducted with samples collected under diverse conditions with multiple freezing and thawing.…”
Section: Introductionmentioning
confidence: 99%