Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: a systematic review

Marroun, Hanan El; White, Tonya; Verhulst, Frank C.; Tiemeier, Henning

doi:10.1007/s00787-014-0558-3

Cited by 86 publications

(69 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One possible cause is that the rates of maternal smoking and antipsychotics among pregnancy women are rare in China. This does not mean that children being exposed to smoking and antipsychotics in utero are risk-free of dyslexia, as it has been shown that maternal smoking and antipsychotics had adverse effect on offspring’s reading ability2140. Finally, we did not obtain the family history of dyslexia and other language disorders, because our team was the first one studying dyslexia in Chinese in Hubei province.…”

Section: Discussionmentioning

confidence: 99%

Descriptive epidemiology of prenatal and perinatal risk factors in a Chinese population with reading disorder

Liu

Wang

Shao

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Several prenatal and perinatal factors have been found to be associated with developmental dyslexia (reading disorder) in alphabetic language. Given the absence of relevant studies of Chinese children, the present study tries to investigate these risk factors. A total of 45,850 students were recruited from grades three to six, from seven cities of Hubei province. Dyslexia in Chinese was diagnosed based on children’s clinical symptoms. The clinical symptoms of children’s reading performance were assessed by Dyslexia Checklist for Chinese Children (DCCC) and Pupil Rating Scale Revised Screening for Learning Disabilities (PRS) which were completed by parent/guardian and header teacher respectively. Chinese language exam was used to screen children with poor reading capacity. Questionnaires about prenatal and perinatal factors were completed by parent or guardian. Among the 34,748 eligible participants, 1,200 (3.45%) were diagnosed with dyslexia in Chinese. More boys suffered from dyslexia than the girls and the gender ratio was 3:1. Family history of neuropsychiatric diseases, maternal infectious diseases, difficult vaginal delivery, preterm birth, and neonatal asphyxia were found to increase the risk of developmental dyslexia in China. Closer longitudinal developmental monitoring and preventive measures should be taken for high risk children.

show abstract

Section: Discussionmentioning

confidence: 99%

Descriptive epidemiology of prenatal and perinatal risk factors in a Chinese population with reading disorder

Liu

Wang

Shao

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Well-designed observational studies and randomized controlled trials (RCTs) have been called for to resolve these conflicting findings [19], but because RCTs involving pregnant women are ethically problematic, observational studies addressing confounding by indication and other potential confounders take precedent [20]. In this study, using data from the Norwegian Mother and Child cohort study (MoBa), we aimed to evaluate whether prenatal exposure to BZDs and z-hypnotics affects internalizing or externalizing behavior problems in children at ages 1.5 and 3 years.…”

Section: Introductionmentioning

confidence: 99%

Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study

et al. 2017

View full text Add to dashboard Cite

BackgroundDuring pregnancy, many women experience sleep problems and anxiety that require treatment. The long-term safety for the child of maternal benzodiazepine (BZD) and z-hypnotic use during pregnancy remains controversial.MethodWe conducted a cohort and a sibling control study using data from the Norwegian Mother and Child Cohort Study. Data on use of BZD and z-hypnotics, internalizing and externalizing outcomes, and covariates were collected from mothers at gestational weeks 17 and 30 and when children were 0.5, 1.5, and 3 years of age. The total sample consisted of 71,996 children (19,297 siblings) at 1.5 years and 55,081 children (13,779 siblings) at 3 years. Short-term use was defined as use in one pregnancy period only. Long-term use was defined as use in two or more pregnancy periods. Linear full cohort random-effect and sibling-matched fixed-effect regression models were used to compare internalizing and externalizing behavior in children prenatally exposed compared to those unexposed in the full cohort of pregnancies accounting for family clusters, as well as within sibling clusters comparing pregnancies with discordant exposures. Propensity score (PS) adjustment included variables on indication for use (sleep problems, symptoms of anxiety and depression) and other potential confounding factors.ResultsLong-term prenatal exposure to BZD or z-hypnotics was associated with increased internalizing behavior in crude cohort analyses and at age 1.5 years after PS adjustment in sibling-matched fixed-effect models [β 0.60, 95% confidence interval 0.17–0.95]. Analyses on specific drug groups showed that prenatal exposure to BZD-anxiolytics was associated with increased internalizing problems at both 1.5 years [β 0.25, 0.01–0.49] and 3 years [β 0.26, 0.002–0.52] while exposure to z-hypnotics was not associated with any adverse outcomes after adjustment.ConclusionThe findings suggest a moderate association between BZD-anxiolytic exposure and child internalizing problems that is not likely due to stable familial confounding factors.

show abstract

“…In the medical literature there are descriptions of a number of studies (Naeye & Peters, 1987;Salova, 2009;Calvigioni & Hurd, 2014;El Marroun, White, Verhulst, & Tiemeier, 2014;Hebebrand & Verhulst, 2014;Sayal, Heron, Draper, Alati, Lewis, Fraser,…, & Gray, 2014;Tiesler & Heinrich, 2014), proving the negative impact of intrauterine hypoxia, including of toxic origin, on the child's mental ontogenesis, even in cases of favorable outcome. Medical research cannot replace the psychological study of the issue.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological analysis of the features of mental development in school age children with mild perinatal hypoxic damage of the nervous system in their anamnesis

Sultanova¹

2018

Psych. Rus.

View full text Add to dashboard Cite

Background. Perinatal pathology of the nervous system (PPNS) of hypoxic genesis is one of the most significant causes of deviations in mental development. It is necessary to investigate the impact of mild PPNS for the child's mental ontogenesis, because coarser perinatal lesions, as a rule, lead to significant violations of development and should be analyzed separately. From our point of view, the qualitative neuropsychological syndromic analysis adopted in Russian child neuropsychology is the most productive way to study this problem.Objective. The purpose of this study was to conduct neuropsychological analysis of the features of mental development of school-age children with mild hypoxic PPNS in their anamnesis.Design. Our research involved 62 children 10-12.5 years old, who were studying in comprehensive schools in Moscow. The main group was comprised of 42 neurologically healthy children who had hypoxic-ischemic encephalopathy of mild severity in their anamnesis. The control group was comprised of 20 neurologically healthy children without indication of pathology of pregnancy and labor in their anamnesis.Methods. We used neuropsychological Luria tests that have been adapted for children, conducted an interview of parents and teachers about the peculiarities of children's behavior, and analyzed electroencephalogram reports.Results. Every child with PPNS exhibited similar features, such as neurodynamic disorders and a lack of voluntary control. We called this symptom complex "subcorticalfrontal" neuropsychological syndrome. In addition, each child in the main group had a failure of at least one neuropsychological factor. The following functions showed insufficiency most often: voluntary attention, speech development, verbal-auditory memory, kinetic and kinesthetic praxis, visual-spatial gnosis, and phonemic hearing. Left hemisphere functions and interhemispheric interaction suffered to a greater degree. The children with PPNS were divided into two subgroups, depending on the severity of the insufficiency of executive functions (EF). Children with severe insufficiency of EF more Neuropsychological analysis of the features of mental development… 29 frequently demonstrated violation of development of verbal-logical thinking, difficulties in social adaptation, emotional disorders, and deviant behavior.Conclusion. The mental development of school-age children with mild PPNS in their anamnesis differs from the development of their peers. We can talk about the longterm consequences of mild hypoxic perinatal damage of the nervous system.Abbreviations. PPNS -perinatal pathology of the nervous system; CNS -central nervous system; EEG -electroencephalogram; EF -executive functions.

show abstract

Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: a systematic review

Cited by 86 publications

References 106 publications

Descriptive epidemiology of prenatal and perinatal risk factors in a Chinese population with reading disorder

Descriptive epidemiology of prenatal and perinatal risk factors in a Chinese population with reading disorder

Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study

Neuropsychological analysis of the features of mental development in school age children with mild perinatal hypoxic damage of the nervous system in their anamnesis

Contact Info

Product

Resources

About