2019
DOI: 10.1073/pnas.1817014116
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Maternal viral infection causes global alterations in porcine fetal microglia

Abstract: Maternal infections during pregnancy are associated with increased risk of neurodevelopmental disorders, although the precise mechanisms remain to be elucidated. Previously, we established a maternal immune activation (MIA) model using swine, which results in altered social behaviors of piglet offspring. These behavioral abnormalities occurred in the absence of microglia priming. Thus, we examined fetal microglial activity during prenatal development in response to maternal infection with live porcine reproduc… Show more

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Cited by 25 publications
(39 citation statements)
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“…The cytokinemediated signaling pathway was also over-represented among the genes under-expressed in MPA relative to CON pigs ( Table 3). Consistent with our results, the expression of 28 genes annotated to immune stimulus had MIA-by-sex interaction effects in the microglia of GD 97 fetuses after GD 76 PRRSV injection (Antonson et al, 2019).…”
Section: Functional Analysis Of Sex-dependent Maternal Immune Activatsupporting
confidence: 90%
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“…The cytokinemediated signaling pathway was also over-represented among the genes under-expressed in MPA relative to CON pigs ( Table 3). Consistent with our results, the expression of 28 genes annotated to immune stimulus had MIA-by-sex interaction effects in the microglia of GD 97 fetuses after GD 76 PRRSV injection (Antonson et al, 2019).…”
Section: Functional Analysis Of Sex-dependent Maternal Immune Activatsupporting
confidence: 90%
“…Several KEGG pathways associated with inflammation and infection, including allograft rejection, Epstein-Barr virus infection, and autoimmune thyroid disease, were enriched, among the genes differentially expressed between MPA and CON pigs ( Table 5 and Supplementary File S1 Table E). This finding is consistent with the significant effect of MIA from GD 76 PRRSV injection on expression of 12 genes in the amygdala of GD 97 fetuses from both sexes (Antonson et al, 2019). At this fetal stage, most of the genes differentially expressed between MPA and CON gilts were annotated to the BP immune response, including genes annotated to the BP cytokine-mediated signaling pathway, and to the toll-like receptor pathway (Antonson et al, 2019).…”
Section: Functional Analysis Of Sex-independent Maternal Immune Activsupporting
confidence: 82%
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