Maternal western diet primes non‐alcoholic fatty liver disease in adult mouse offspring

Pruis, Maurien; Lendvai, Ágnes; Bloks, Vincent W.; Zwier, Mathijs V.; Baller, Jfw; Bruin, Alain de; Groen, Albert K.; Plösch, Torsten

doi:10.1111/apha.12197

Cited by 84 publications

(70 citation statements)

References 49 publications

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“…Evidence was found of early steatohepatitis similar to type II NASH, which is the most usual in paediatric NAFLD (Schwimmer et al 2005). Occurrence of NAFLD after prenatal programming has been previously found in male mice and not in female mice, but in the first generation and during adulthood (Pruis et al 2014), which supports the susceptibility of the Iberian pigs to changes in nutritional and metabolic status.…”

Section: Discussionmentioning

confidence: 53%

Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance

González-Bulnes¹,

Astiz²,

Óvilo³

et al. 2014

Journal of Endocrinology

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Maternal malnutrition during pregnancy, both deficiency and excess, induces changes in the intrauterine environment and the metabolic status of the offspring, playing a key role in the growth, status of fitness/obesity and appearance of metabolic disorders during postnatal life. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations. This study evaluated, in a swine model of obesity/leptin resistance, the existence and extent of transgenerational developmental programming effects. Pre-and postnatal development, adiposity and metabolic features were assessed in the second generation of piglets, descendant of sows exposed to either undernutrition or overnutrition during pregnancy. The results indicated that these piglets exhibited early-postnatal increases in adiposity and disturbances in lipid profiles compatible with the early prodrome of metabolic syndrome, with liver tissue also displaying evidence of paediatric liver disease. These features indicative of early-life metabolic disorders were more evident in the males that were descended from overfed grandmothers and during the transition from milk to solid feeding. Thus, this study provides evidence supporting transgenerational developmental programming and supports the necessity for the development of strategies for avoiding the current epidemics of childhood overweight and obesity.

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Section: Discussionmentioning

confidence: 53%

Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance

González-Bulnes¹,

Astiz²,

Óvilo³

et al. 2014

Journal of Endocrinology

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“…However, this effect is markedly exaggerated when the dams and offspring (CAF-CAF F1 ) have been exposed to CAF diet throughout life. As previously demonstrated by Bruce et al (2009) and Pruis et al (2014), the higher hepatic lipid accumulation in offspring could be attributed to up-regulation of de novo fatty acid synthesis, failure to up-regulate mitochondrial beta oxidation and fatty acid export. Animal models indicate that programmed effects, in particular hepatic steatosis, are highly irreversible after weaning.…”

Section: Maternal Diet Leads To Morphological Changes In Offspring 2895supporting

confidence: 52%

“…In contrast, Bringhenti et al (2011) reported that introducing fish oil to a post weaning diet can reverse maternal low protein diet induced hepatic steatosis in offspring. It probable that epigenetic events induced by maternal overnutrition leads to altered DNA methylation pattern of the offspring during their development and influencing their later health (Pruis et al 2014).…”

Section: Maternal Diet Leads To Morphological Changes In Offspring 2895mentioning

confidence: 99%

Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats

Santos

Balbo

Guimarães

et al. 2017

An. Acad. Bras. Ciênc.

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Here, we evaluated whether the exposure of rats to a cafeteria diet pre-and/or post-weaning, alters histological characteristics in the White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and liver of adult male offspring. Female Wistar rats were divided into Control (CTL; fed on standard rodent chow) and Cafeteria (CAF; fed with the cafeteria diet throughout life, including pregnancy and lactation). After birth, only male offspring (F1) were maintained and received the CTL or CAF diets; originating four experimental groups: CTL-CTL F1 ; CTL-CAF F1 ; CAF-CTL F1 ; CAF-CAF F1 . Data of biometrics, metabolic parameters, liver, BAT and WAT histology were assessed and integrated using the Principal Component Analysis (PCA). According to PCA analysis worse metabolic and biometric characteristics in adulthood are associated with the post-weaning CAF diet compared to pre and post weaning CAF diet. Thus, the CTL-CAF F1 group showed obesity, higher deposition of fat in the liver and BAT and high fasting plasma levels of glucose, triglycerides and cholesterol. Interestingly, the association between pre and post-weaning CAF diet attenuated the obesity and improved the plasma levels of glucose and triglycerides compared to CTL-CAF F1 without avoiding the higher lipid accumulation in BAT and in liver, suggesting that the impact of maternal CAF diet is tissue-specific.

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“…As an editor, you actually have a chance to get to the bottom of this question by taking a measure for quality (downloads or citations) and correlating that with the referees' scoring. The results are indeed surprising, as demonstrated by our five most cited original articles in 2014 (Boushel et al 2014, Pruis et al 2014, Yu et al 2014(Chen et al 2015, Dahl et al 2015, Heimlich et al 2015, Tam et al 2015, Uchida et al 2015.…”

mentioning

confidence: 84%

Who can be more ignorant than an editor?

Persson

2016

Acta Physiologica

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Maternal western diet primes non‐alcoholic fatty liver disease in adult mouse offspring

Abstract: Maternal dietary fat intake during early development programmes susceptibility to liver disease in male offspring, mediated by disturbances in lipid metabolism and inflammatory response. Long-lasting epigenetic changes may underlie this dysregulation.

Cited by 84 publications

References 49 publications

Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance

Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance

Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats

Who can be more ignorant than an editor?

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