Maternal Western-style diet reduces social engagement and increases idiosyncratic behavior in Japanese macaque offspring

Mitchell, Alex J.; Khambadkone, Seva G.; Dunn, Geoffrey A.; Bagley, Jennifer L.; Tamashiro, Kellie L.K.; Fair, Damien A.; Gustafsson, Hanna; Sullivan, Elinor L.

doi:10.1016/j.bbi.2022.07.004

Cited by 9 publications

(6 citation statements)

References 106 publications

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“…The results of this research suggest that obesity caused by a high‐fat diet during pregnancy may increase the susceptibility of offspring to neurological diseases by disrupting communication between the placenta and the fetal brain, thus providing evidence for targeted dietary regulation in pregnant women to reduce the risk of psychiatric disorders in their offspring. In addition to increasing the risk of psychiatric disorders in offspring as a result of maternal obesity, a high intake of saturated fat and sugar during pregnancy is also associated with increased levels of interleukin‐2, which leads to inflammation‐mediated neurodevelopmental disorders (Mitchell et al., 2022). As a result, pregnant women, especially those with obesity, should avoid a Western diet or similar diets that are high in fat and sugar.…”

Section: Dietary Recommendations For Pregnant Women With Potential Risksmentioning

confidence: 99%

Dietary nutrients that potentially mitigate autism spectrum disorder and dietary recommendations for children and pregnant women

Li,

Kong,

Tian

et al. 2024

Food Frontiers

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The increasing incidence of autism spectrum disorder (ASD) worldwide poses serious social and family problems. Various risk factors for ASD are gradually being recognized, and there are also various options for the treatment of ASD. It is worth noting that dietary interventions have been shown to have a positive effect in terms of mitigating and preventing some psychiatric disorders, such as epilepsy, Parkinson's disease, and ASD, and they are gradually receiving attention as a safe adjuvant treatment. In this review, based on the current understanding of the pathogenic factors and intervention strategies for ASD, different dietary patterns that can be selected for children with ASD are discussed in depth. Moreover, a review was conducted on the use of dietary factors, such as natural products from food sources, prebiotics, and probiotics, as effective supplements to existing dietary patterns. As increasing evidence shows that maternal risk factors, such as obesity, diabetes, and hypertension, are associated with an increased risk of ASD in offspring, dietary suggestions are also made for pregnant woman with ASD‐related risk factors to counteract the impact of these risk factors. With compensation from food‐derived natural products, prebiotics, and probiotics, suitable dietary patterns can further enhance the effectiveness of dietary interventions for ASD. In addition, dietary recommendations for pregnant woman may reduce the potential impact of obesity, diabetes, and hypertension and may help to prevent the occurrence of ASD to the maximum extent possible.

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Section: Dietary Recommendations For Pregnant Women With Potential Risksmentioning

confidence: 99%

Dietary nutrients that potentially mitigate autism spectrum disorder and dietary recommendations for children and pregnant women

Li,

Kong,

Tian

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

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“…The exact cause of these relationships is not entirely clear. However, further research by this group found that IL-12 was increased in the dams due to maternal WSD, which caused neurodevelopmental disorders in the offspring [ 98 ]. Another group confirmed the previous findings of decreased microglial cell counts due to maternal WSD but also showed that the deceased cell count did not persist one year postnatally [ 99 ].…”

Section: Microglia Activation By a Maternal Wsdmentioning

confidence: 99%

Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring

Nelson,

Friedman

2024

IJMS

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Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life. Children born to mothers with obesity have reduced immune responses to stimuli which increase susceptibility to infections. Recently, maternal western-style diets (WSDs), high in fat and simple sugars, have been associated with skewing neonatal immune cell development, and recent evidence suggests that dysregulation of innate immunity in early life has long-term consequences on metabolic diseases and behavioral disorders in later life. Several factors contribute to abnormal innate immune tolerance or trained immunity, including changes in gut microbiota, metabolites, and epigenetic modifications. Critical knowledge gaps remain regarding the mechanisms whereby these factors impact fetal and postnatal immune cell development, especially in precursor stem cells in bone marrow and fetal liver. Components of the maternal microbiota that are transferred from mothers consuming a WSD to their offspring are understudied and identifying cause and effect on neonatal innate and adaptive immune development needs to be refined. Tools including single-cell RNA-sequencing, epigenetic analysis, and spatial location of specific immune cells in liver and bone marrow are critical for understanding immune system programming. Considering the vital role immune function plays in offspring health, it will be important to understand how maternal diets can control developmental programming of innate and adaptive immunity.

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“…Studies have linked several prenatal exposures to neurodevelopmental disorders in children, including maternal obesity, metabolic disturbances, stress, and individual nutritional elements (8). Numerous animal studies have shown that high-fat diets can alter brain morphology (9) and behaviour in offspring in ways resembling neurodevelopmental disorders (10,11), however these findings may not extrapolate well to humans.…”

Section: Introductionmentioning

confidence: 99%

A Western Dietary Pattern during Pregnancy is Associated with Neurodevelopmental Disorders in Childhood and Adolescence

Horner,

Jepsen,

Chawes

et al. 2024

Preprint

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Despite the high prevalence of neurodevelopmental disorders, there are a lack of clinical studies examining the impact of pregnancy diet on child neurodevelopment. This observational clinical study examined the associations between pregnancy dietary patterns and neurodevelopmental diagnoses, as well as their symptoms, in a prospective cohort of 10-year-old children (n=508). Data-driven dietary patterns were derived from self-reported food frequency questionnaires. An Unhealthy dietary pattern in pregnancy (per SD change) was significantly associated with attention deficit hyperactivity disorder (ADHD) OR 1.66 [1.21 - 2.27], p=0.002 and autism diagnosis OR 2.22 [1.33 - 3.74], p=0.002 and associated symptoms p<0.001. Findings for ADHD were validated in two large (n=656, n=348), independent mother-child cohorts via blood metabolome modelling. Objective metabolite scores, assessed at five timepoints in mothers and children in two independent mother-child cohorts, indicated that the strongest association with ADHD was during early- to mid- pregnancy. These results provide evidence for targeted prenatal dietary interventions to prevent neurodevelopmental disorders in children.

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Maternal Western-style diet reduces social engagement and increases idiosyncratic behavior in Japanese macaque offspring

Cited by 9 publications

References 106 publications

Dietary nutrients that potentially mitigate autism spectrum disorder and dietary recommendations for children and pregnant women

Dietary nutrients that potentially mitigate autism spectrum disorder and dietary recommendations for children and pregnant women

Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring

A Western Dietary Pattern during Pregnancy is Associated with Neurodevelopmental Disorders in Childhood and Adolescence

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