Maternal zinc supplementation improves hepatitis B antibody responses in infants but decreases plasma zinc level

Ahmad, Shaikh Meshbahuddin; Hossain, Mohammad Bakhtiar; Monirujjaman, Md.; Islam, Sharmin; Huda, Md. Nazmul; Kabir, Yearul; Raqib, Rubhana; Lönnerdal, Bo

doi:10.1007/s00394-015-0999-6

Cited by 19 publications

(45 citation statements)

References 33 publications

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“…Post-hoc subgroup analyses were conducted for all outcomes, across all comparisons when ≥three studies per subgroup of interest were available. [49,[95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112]). Seven studies were conducted in Latin America and the Caribbean [48,[113][114][115][116][117][118], and only one trial was conducted in Europe and Central Asia (Turkey; [52]).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies evaluated zinc supplementation compared to placebo in women during pregnancy [53,56,66,74,91,94,95,98,99,103,114,115,117]. Prawirohartono et al was not included in meta-analysis because it reported no poolable outcomes, but was narratively synthesized [53] (see Supplementary Materials, Table S3).…”

Section: Zinc Supplementation Versus Placebomentioning

confidence: 99%

“…Prawirohartono et al was not included in meta-analysis because it reported no poolable outcomes, but was narratively synthesized [53] (see Supplementary Materials, Table S3). Of these, twelve were included in the meta-analyses [56,66,74,91,94,95,98,99,103,114,115,117]. Four studies were conducted in South Asia, with two of these conducted in Bangladesh [95,103], one in Pakistan [99], and one in Nepal [98].…”

Section: Zinc Supplementation Versus Placebomentioning

confidence: 99%

“…Of these, twelve were included in the meta-analyses [56,66,74,91,94,95,98,99,103,114,115,117]. Four studies were conducted in South Asia, with two of these conducted in Bangladesh [95,103], one in Pakistan [99], and one in Nepal [98]. Three studies were conducted in Latin America and the Caribbean, specifically two in Peru [115,117] and on in No subgroup analysis for primary outcomes was possible for this comparison due to an insufficient number of studies per subgroup of interest.…”

Section: Zinc Supplementation Versus Placebomentioning

confidence: 99%

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Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

2020

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Almost two billion people are deficient in key vitamins and minerals, mostly women and children in low- and middle-income countries (LMICs). Deficiencies worsen during pregnancy due to increased energy and nutritional demands, causing adverse outcomes in mother and child, but could be mitigated by interventions like micronutrient supplementation. To our knowledge, this is the first systematic review that aimed to compile evidence from both efficacy and effectiveness trials, evaluating different supplementation interventions on maternal, birth, child health, and developmental outcomes. We evaluated randomized controlled trials and quasi-experimental studies published since 1995 in peer-reviewed and grey literature that assessed the effects of calcium, vitamin A, iron, vitamin D, and zinc supplementation compared to placebo/no treatment; iron-folic (IFA) supplementation compared to folic acid only; multiple micronutrient (MMN) supplementation compared to IFA; and lipid-based nutrient supplementation (LNS) compared to MMN supplementation. Seventy-two studies, which collectively involved 314 papers (451,723 women), were included. Meta-analyses showed improvement in several key birth outcomes, such as preterm birth, small-for-gestational age (SGA) and low birthweight with MMN supplementation, compared to IFA. MMN also improved child outcomes, including diarrhea incidence and retinol concentration, which are findings not previously reported. Across all comparisons, micronutrient supplementation had little to no effect on mortality (maternal, neonatal, perinatal, and infant) outcomes, which is consistent with other systematic reviews. IFA supplementation showed notable improvement in maternal anemia and the reduction in low birthweight, whereas LNS supplementation had no apparent effect on outcomes; further research that compares LNS and MMN supplementation could help understand differences with these commodities. For single micronutrient supplementation, improvements were noted in only a few outcomes, mainly pre-eclampsia/eclampsia (calcium), maternal anemia (iron), preterm births (vitamin D), and maternal serum zinc concentration (zinc). These findings highlight that micronutrient-specific supplementation should be tailored to specific groups or needs for maximum benefit. In addition, they further contribute to the ongoing discourse of choosing antenatal MMN over IFA as the standard of care in LMICs.

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Section: Resultsmentioning

confidence: 99%

Section: Zinc Supplementation Versus Placebomentioning

confidence: 99%

Section: Zinc Supplementation Versus Placebomentioning

confidence: 99%

Section: Zinc Supplementation Versus Placebomentioning

confidence: 99%

See 2 more Smart Citations

Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

2020

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“…It started in 1979 as a pilot project to eradicate or eliminate some vaccine preventable diseases [36]. HBV vaccine has been incorporated in EPI schedule since 2004 in Bangladesh and immunoprophylaxis of babies of HBsAg positive mother and post exposure prophylaxis are effective ways of prevention [37]. As many as 90% of infants born to Hepatitis B e Antigen (HBeAg) positive mothers become carriers themselves and, therefore, in long term are more likely to develop chronic liver disease [38].…”

Section: Overview On Epi and Hbv Vaccination In Bangladeshmentioning

confidence: 99%

Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

Alam¹

2017

GHOA

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Chronic hepatitis B (HBV) is one of the major diseases of mankind, estimated to cause about 686,000 deaths per year mostly from liver cancer and cirrhosis. And globally about 240 million people are chronically infected with hepatitis B. Nonalcoholic fatty liver disease (NAFLD) is an emerging commonest cause of chronic liver disease in the world. We have searched for CHB, NAFLD in PUBMED, Google scholar and local journals and related available articles were included in this review. Along with 184 countries of the world Bangladesh adopted hepatitis B vaccine in his EPI (expanded program on immunization) schedule for its prevention. And now about 95% of children are under cover of Hepatitis vaccine. Along with globally in last two decades' seroprevalence of HBsAg reduced about four times in Bangladesh. The prevalence of recorded nonalcoholic fatty liver disease (NAFLD) varies considerably by ethnic group and Bangladeshi ethnicity is an independent risk factor for NAFLD. The prevalence of NAFLD in Bangladesh is vary from 4%-18.4% and it is increasing day by day. About 40% of them are nonalcoholic steatohepatitis (NASH). They are in danger of progression to cirrhosis and hepatocellular carcinoma (15-19%) in next 5 to 10 years. Now it's becoming a silent killer for our nation. Gradual development of affluence, sedentary life style and increasing prevalence of diabetes contributed behind it. No effective treatment is available till now. Life style change by diet, exercise and weight reduction is the main stay of treatment. NAFLD involve multiple organs that leads to death due to cardiac, neurological and liver disease. Government and health department should take multidisciplinary action programs in awareness building and make a national guideline for fatty liver management.

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Zinc supplementation for improving pregnancy and infant outcome

Carducci

Keats

Bhutta

2021

Cochrane Database of Systematic Reviews

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Maternal zinc supplementation improves hepatitis B antibody responses in infants but decreases plasma zinc level

Abstract: Prenatal and postnatal zinc supplementation marginally improved T cell-dependent antibody responses in infants along with IL-7, a cytokine involved in human T cell development and maintaining homeostasis.

Cited by 19 publications

References 33 publications

Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

Zinc supplementation for improving pregnancy and infant outcome

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