Maternally involved galanin neurons in the preoptic area of the rat

Cservenák, Melinda; Kis, Viktor; Keller, David W.; Dimén, Diána; Menyhárt, Lilla; Oláh, Szilvia; Szabó, Erika; Barna, János; Renner, Éva; Usdin, Ted B.; Dobolyi, Árpád

doi:10.1007/s00429-016-1246-5

Cited by 29 publications

(35 citation statements)

References 92 publications

(126 reference statements)

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“…Thus, the present study was not able to identify a predominant neurotransmitter or neuropeptide that is co‐produced by MCH cells in the mPOA during late lactation. Other neuropeptides are produced by mPOA neurones, including galanin, CART, cholecystokinin, corticotrophin‐releasing factor, neurokinin A and substance P, amongst others . Galanin cells are particularly interesting because POA neurones producing this neuropeptide are implicated in the control of parental behaviours, a function also attributed to mPOA MCH neurones.…”

Section: Discussionmentioning

confidence: 99%

“…Other neuropeptides are produced by mPOA neurones, including galanin, CART, cholecystokinin, corticotrophin‐releasing factor, neurokinin A and substance P, amongst others . Galanin cells are particularly interesting because POA neurones producing this neuropeptide are implicated in the control of parental behaviours, a function also attributed to mPOA MCH neurones. Therefore, future studies can determine whether MCH neurones in the mPOA co‐express neuropeptides that were not investigated in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Teixeira

Wasinski

Lima

et al. 2019

J Neuroendocrinology

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Neurones expressing the melanin‐concentrating hormone (MCH) can be found in the medial preoptic area (mPOA) and ventral aspects of the periventricular preoptic nucleus of rats by mid‐to‐late lactation and this expression disappears after weaning. The transitory expression of MCH in the preoptic area suggests a role for these neurones in the control of the end of lactation. However, the neurochemical identity of mPOA MCH neurones and the regulatory factors that control the transient MCH expression remain largely unknown, especially in the mouse. In the present study, we showed that mice also present the transitory expression of MCH in the mPOA at late lactation. mPOA MCH cells did not colocalise significantly with markers of GABAergic (VGAT), glutamatergic (VGLUT2 and VGLUT3) or dopaminergic (tyrosine hydroxylase) neurones. mPOA MCH cells also did not express Kiss1 or oxytocin. By contrast, approximately 70% and 90% of mPOA MCH neurones colocalised with oestrogen receptor α and prolactin‐induced phosphorylated signal transducer and activator of transcription 5 (STAT5), respectively. Finally, we demonstrated that the number of MCH neurones in the mPOA is significantly higher in females during the first lactation, compared to mice on the second lactation or pregnant mice during the first lactation or brain‐specific STAT5 knockout mice during the first lactation. In summary, our findings indicate that MCH neurones in the mPOA of lactating mice are sensitive to oestrogens and prolactin. Thus, mPOA MCH expression is possibly influenced by hormonal variations. Furthermore, the STAT5 signalling pathway is likely involved in the regulation of MCH expression in the mPOA of lactating mice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Teixeira

Wasinski

Lima

et al. 2019

J Neuroendocrinology

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“…Not dissimilar to the PVN, Prlr-expressing cells of the MPOA were also less responsive to an acute application of prolactin. The MPOA consists of a highly heterogeneic population of neuronal cell types which are closely linked to the regulation of maternal and paternal behaviours [33,[46][47][48][49][50]. Indeed, prolactin's role in offspring care has been attributed to the expression of Prlrs in this brain region [10,33].…”

Section: Discussionmentioning

confidence: 99%

Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse

Georgescu

Ladyman

Brown

et al. 2020

Preprint

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The anterior pituitary hormone, prolactin, is a fundamental regulator of lactation, and also plays a role in many other physiological processes including maternal behaviour, reproduction, immune response and even energy balance. Indeed, prolactin receptors (Prlr) are widely distributed throughout the body, including a number of different brain regions, further attesting to its pleiotropic nature. Within the brain, previous research has identified key areas upon which prolactin exerts effects on gene transcription through the canonical JAK2/STAT5 pathway downstream of the Prlr. In some neurones, however, such as the tuberoinfundibular dopamine neurones that control prolactin secretion, prolactin can also exert rapid actions to stimulate neuronal activity.While prolactin-induced activation of STAT5 has been described in a wide variety of brain regions, its capacity for acute modulation of electrical properties of many Prlrexpressing neurones remains to be elucidated. To investigate how widespread these rapid actions of prolactin are in various Prlr-expressing neurones, we utilised a transgenic mouse line in which Cre recombinase is specifically expressed in the coding region of the prolactin long form receptor gene (Prlr-iCre). This mouse line was crossed with a Cre-dependent calcium indicator (GCaMP6f) transgenic mouse, allowing us to visually monitor the electrical activity of Prlr-expressing neurones in ex vivo 200µm brain slice preparations. Here, we survey hypothalamic regions implicated in prolactin's diverse physiological functions such as: the arcuate (ARC) and paraventricular nuclei of the hypothalamus (PVN), and the medial preoptic area (MPOA). We observe that in both males and virgin and lactating females, bath application of prolactin is able to induce electrical changes in a subset of Prlrexpressing cells in all of these brain regions. The effects we detected ranged from rapid or sustained increases in intracellular calcium to inhibitory effects, indicating a heterogeneous nature of these Prlr-expressing populations. These results enhance our understanding of mechanisms by which prolactin acts on hypothalamic neurones and provide insights into how prolactin might influence neuronal circuits in the mouse brain.

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“…Another brain region that shows intense activation in rodents but not in the zebra finch is the PIL. This brain region is thought to play a role in the relay of suckling information to the hypothalamus (Cservenák et al, ; Cservenák, Keller, et al, ; Cservenák, Kis, et al, ). The lack of the above‐discussed behaviors in birds may provide an explanation for why these brain regions did not show increased neuronal activation in response to the presence of the nestlings in the zebra finch.…”

Section: Discussionmentioning

confidence: 99%

Neuronal activation in zebra finch parents associated with reintroduction of nestlings

Fazekas

Morvai

Zachár

et al. 2019

J of Comparative Neurology

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Recent studies of the brain mechanisms of parental behaviors have mainly focused on rodents. Using other vertebrate taxa, such as birds, can contribute to a more comprehensive, evolutionary view. In the present study, we investigated a passerine songbird, the zebra finch (Taeniopygia guttata), with a biparental caring system. Parentingrelated neuronal activation was induced by first temporarily removing the nestlings, and then, either reuniting the focal male or female parent with the nestlings (parental group) or not (control group). To identify activated neurons, the immediate early gene product, Fos protein, was labeled. Both parents showed an increased level of parental behavior following reunion with the nestlings, and no sexual dimorphism occurred in the neuronal activation pattern. Offspring-induced parental behavior-related neuronal activation was found in the preoptic, ventromedial (VMH), paraventricular hypothalamic nuclei, and in the bed nucleus of the stria terminalis. In addition, the number of Fos-immunoreactive (Fos-ir) neurons in the nucleus accumbens predicted the frequency of the feeding of the nestlings. No difference was found in Fos expression when the effect of isolation or the presence of the mate was examined. Thus, our study identified a number of nuclei involved in parental care in birds and suggests similar regulatory mechanisms in caring females and males. The activated brain Abbreviations: ABC, avidin-biotin-peroxidase complex; ac, anterior commissure; Acc, nucleus accumbens; AIC, Akaike information criterion; AVP, arginine-vasopressin; BSA, bovine serum albumin; BST, bed nucleus of the stria terminalis; BSTl, lateral subdivision of the bed nucleus of the stria terminalis; BSTmd, mediodorsal subdivision of the bed nucleus of the stria terminalis; BSTmv, medioventral subdivision of the bed nucleus of the stria terminalis;

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Maternally involved galanin neurons in the preoptic area of the rat

Cited by 29 publications

References 92 publications

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse

Neuronal activation in zebra finch parents associated with reintroduction of nestlings

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