Materno-Fetal Transfer of Thyroxine (T4): Maternal (M) and Fetal (F) Free T4 (Ft4) Relationship and Thyromimetic Effects in the Fetus

Abstract

C h a s n o f f , William J . B u r n s a n d K a y r e e n B u r n s .( S p o n . b y S t a n S h u l m a n ) . N o r t h w e s t e r n U n i v e r s i t v Medical School. D e~a r tm e n t s of P e d i a t r~c s a n d P s y c h i a t r y , C h~c a g o .In o r d e r t o ? v a l u a t e t h e e f f e c t s of maternal a b u s e o f nonn a r c o t i c d r u g s d u r i n g p r e g n a n c y , f o u r g r o u p s of i n f a n t s b o r n t o d r u g -a d d i c t e d m o t h e r s w e r e e v a l u a t e d a n d compared t o a c o n t r o l g r o u p of n o r m a l s . G r o u p I i n f a n t s (N=51) w e r e d e l i v e r e d t o m o t h e r s o n methadone m a i n t e n a n c e , G r o u p I1 i n f a n t s (N=22) t o s e d a t i v e / s t i m u l a n t ( n o n n a r c o t i c ) -a b u s i n g m o t h e r s , G r o u p 111 (N=13) t o T ' s a n d b l u e s -a b u s i n g m o t h e r s , G r o u p IV (N=9) t o P C P -a b u s i n g m o t h e r s a n d G r o u p V (N=27) t o m o t h e r s who h a d n o e v i d e n c e of d r u g a b u s e .All f i v e g r o u p s w e r e similar in maternal a g e , g r a v i d i t y , socioeconomic c l a s s a n d neonatal g e s t ational a g e . S i g n i f~c a n t d e c r e a s e s in w e i g h t , l e n g t h a n d h e a d c i r c u m f e r e n c e a t b i r t h w e r e f o u n d (ANOVA) f o r t h e n a r c o t i ce x p o s e d ( G r o u p s I a n d 111) i n f a n t s while n o n n a r c o t i c -e x p o s e d i n f a n t s d e m o n s t r a t e d normal g r o w t h p a r a m e t e r s a t b i r t h . Using t h e BNBAS, G r o u p I i n f a n t s d e m o n s t r a t e d d e f i c i t s in visual a n d a u d i l o r y o r i e n t a t i o n a n d motor m a t u r i t y .All f o u r g r o u p s of d r u g -e x p o s e d n e o n a t e s d e m o n s t r a t e d d e f i c i t s in s t a t e c o n t r o l . G r o u p IV i n f a n t s , in a d d i t i o n , s h o w e d ~n c r e a s e d lability o f s t a t e a n d p o o r consolability when c o m p a r e d t o all o t h e r d r u g g r o u p s ( F i s c h e r ' s L S D ) .On t h e Bayley S c a l e s , s c o r e s f o r all g r o u p s , i n c l u d i n g t h e c o n t r o l , b e g a n t o fall away from t h e normal r a n g e a t 18 m o n t h s of a g e , a phenomenon n o t uncommon in i n f a n t s f r o m lower socioeconomic homes. -S e m F c o n c e n t r a t i o n i n c r e a s e d w i t h repeated d o s e s beyond that expected f o r the r e p o r t e d plasma t+ o f 7-19 hrs. S~& F concentration a f t e r the second dose was s i g n i f i c a n t l y h i g h e r than F level a f t e r the initial o b s e r v e d when g i v e n f r e q u e n t repeated d o s e s o f F to n e w t o m inf a n t s . REGIONAL CEREBRAL BLOOD FLOW (CBF) DURING BICUCULLINE INDUCED SEIZURES ( S ) IN THE NEWBORN PIGLET WITH OR332 WITHOUT PHENOBARBITAL (PB). M . CLOZEL, P. MONIN, J . L . DAVAL, P. VERT, C e n t r e de Recherche B i o l o g i e Medecine du DCvelop--pement Humain, U n i v e r s i t e de NANCY I , FRANCE. I n a d u l t a n i m a l s , S induce i m ...