Mathematical analysis for the dynamics of snakebite envenoming

Abdullahi, Shuaibu Ahijo; Habib, Abdulrazaq Garba; Hussaini, Nafiu

doi:10.1007/s13370-023-01156-3

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Snakebite envenoming is a major burden on global health. − More than 5.4 million annual snakebites cause more than 150,000 casualties and several more long-lasting physical as well as often neglected mental disabilities. − Responsible for a high number of these snake encounters are, beside elapids (Elapidae) and pit vipers (Crotalinae), the “true” or Old World vipers (Viperinae) . Several taxa within this subfamily are in the focus of epidemiological snakebite envenoming dynamics and venom research. − Among them, are the particularly relevant Palearctic vipers of the genera: Vipera, Montivipera, Macrovipera and Daboia. They consist of about 35 species, but their taxonomic classification has been a topic of debate for long time. − The World Health Organization WHO lists all four genera at the highest medical importance, Category 1, with strong impact across their distributions. ,,− …”

Section: Introductionmentioning

confidence: 99%

Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Türkiye

Damm,

Karış,

Petras

et al. 2024

J. Proteome Res.

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Snake venom variations are a crucial factor to understand the consequences of snakebite envenoming worldwide, and therefore it is important to know about toxin composition alterations between taxa. Palearctic vipers of the genera Vipera, Montivipera, Macrovipera, and Daboia have high medical impacts across the Old World. One hotspot for their occurrence and diversity is Turkiye, located on the border between continents, but many of their venoms remain still understudied. Here, we present the venom compositions of seven Turkish viper taxa. By complementary mass spectrometry-based bottom-up and topdown workflows, the venom profiles were investigated on proteomics and peptidomics level. This study includes the first venom descriptions of Vipera berus barani, Vipera darevskii, Montivipera bulgardaghica albizona, and Montivipera xanthina, as well as the first snake venomics profiles of Turkish Macrovipera lebetinus obtusa, and Daboia palaestinae, including an in-depth reanalysis of M. bulgardaghica bulgardaghica venom. Additionally, we identified the modular consensus sequence pEXW(PZ) 1−2 P(EI)/(KV)PPLE for bradykinin-potentiating peptides in viper venoms. For better insights into variations and potential impacts of medical significance, the venoms were compared against other Palearctic viper proteomes, including the first genus-wide Montivipera venom comparison. This will help the risk assessment of snakebite envenoming by these vipers and aid in predicting the venoms' pathophysiology and clinical treatments.

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Section: Introductionmentioning

confidence: 99%

Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Türkiye

Damm,

Karış,

Petras

et al. 2024

J. Proteome Res.

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Venomics and Peptidomics of Palearctic vipers: Clade-wide analysis of seven taxa of the generaVipera,Montivipera,MacroviperaandDaboiaacross Türkiye

Damm,

Karış,

Petras

et al. 2024

Preprint

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Snake venom variations are a crucial factor to understand the consequences of snakebite envenoming worldwide and therefore it's important to know about toxin composition alterations between taxa. Palearctic vipers of the generaVipera,Montivipera,MacroviperaandDaboiahave high medical impacts across the Old World. One hotspot for their occurrence and diversity is Türkiye on the border between the continents, but many of their venoms remain still understudied. Here, we present the venom compositions of seven Turkish viper taxa. By complementary mass spectrometry-based bottom-up and top-down workflows, the venom profiles were investigated on proteomics and peptidomics level. This study includes the first venom descriptions ofVipera berus barani,Vipera darevskii,Montivipera bulgardaghica albizonaandMontivipera xanthina, as well as first snake venomics profiles of TurkishMacrovipera lebetinus obtusaandDaboia palaestinae, including an in-depth reanalysis ofMontivipera bulgardaghica bulgardaghicavenom. Additionally, we identified the modular consensus sequence pEXW(PZ)1-2P(EI)/(KV)PPLE for bradykinin-potentiating peptides (BPP) in viper venoms. For better insights into variations and potential impacts of medical significance the venoms were compared against other Palearctic viper proteomes, including the first genus-wideMontiviperavenom comparison. This will help the risk assessment of snakebite envenoming by these vipers and aid in predicting the venoms pathophysiology and clinical treatments.

show abstract

Mathematical analysis for the dynamics of snakebite envenoming

Cited by 2 publications

References 45 publications

Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Türkiye

Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Türkiye

Venomics and Peptidomics of Palearctic vipers: Clade-wide analysis of seven taxa of the generaVipera,Montivipera,MacroviperaandDaboiaacross Türkiye

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