2004
DOI: 10.1016/j.mbs.2004.06.007
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Mathematical analysis of competition between sensory ganglion cells for neurotrophic factor in the skin

Abstract: A model is presented of competition between sensory axons for trophic molecules (e.g. a neurotrophin such as NGF), produced in a region of skin small enough to permit their free diffusion throughout it; e.g., a touch dome, or a vibrissal follicle hair sinus. The variables specified are the number of high affinity trophic factor receptors per axon terminal and the concentration of trophic factor in the extracellular space. Previous models of this class predicted the loss of all the axons innervating the region … Show more

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Cited by 1 publication
(1 citation statement)
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“…Developing appropriate tunable biomaterials for a systematic study of neuronal cell growth and differentiation is another important aspect that is considered by many groups [135,[250][251][252], and has resulted in functional materials for improving axonal development [253]. Moreover, computational studies have been employed for predicting the mechanism of neurotrophic factor gradient generation, polarization of growth cone receptors, and cytoskeleton organization [254][255][256][257][258].…”
Section: Neuronal Axon Developmentmentioning
confidence: 99%
“…Developing appropriate tunable biomaterials for a systematic study of neuronal cell growth and differentiation is another important aspect that is considered by many groups [135,[250][251][252], and has resulted in functional materials for improving axonal development [253]. Moreover, computational studies have been employed for predicting the mechanism of neurotrophic factor gradient generation, polarization of growth cone receptors, and cytoskeleton organization [254][255][256][257][258].…”
Section: Neuronal Axon Developmentmentioning
confidence: 99%