Mathematical analysis of intercellular calcium propagation induced by adenosine triphosphate

Abstract

The method we present here should be useful to analyze the effects of various reagents in in vitro studies.

Ryanodine Receptors Are Expressed in Epidermal Keratinocytes and Associated with Keratinocyte Differentiation and Epidermal Permeability Barrier Homeostasis

“…It has been shown that IP3 receptor is associated with TRPV3 signaling in mouse keratinocytes (Cheng et al, 2010). We recently demonstrated that IP3 had an important role in calcium propagation in cultured human keratinocytes (Tsutsumi et al, 2010). RyR is expressed in the ER or sarcoplasmic reticulum in muscle.…”

Mathematical Modeling of Calcium Waves Induced by Mechanical Stimulation in Keratinocytes

“…Moreover, abnormal calcium gradients in the epidermis have been observed in a variety of skin diseases [6], and the mutation of the calcium pump or gap junctions is known to induce genetic skin diseases [7]–[9]. In addition, it has been reported that information regarding the stimuli, damage status, and the skin pathology are reflected in the features of calcium wave propagation and distribution in cultured keratinocytes [10], [11]. Therefore, understanding the mechanisms of the dynamical behavior of the calcium distribution in the epidermal keratinocytes should provide us with clues regarding the possible treatment of various skin diseases.…”

Epidermal Keratinocyte Sensing and Processing of Environmental Information Together with the Brain’s Simulation and Prediction Abilities Helped to Enable <i>Homo sapiens’</i> Evolutionary Success

“…For example, when different-shaped molds were pressed on the fingertip, different electrophysiological patterns were observed in peripheral nerves of the forearm, suggesting that geometrical information may be recognized by the skin (Pruszynski & Johansson, 2014). Also, we have observed distinct spatiotemporal patterns of calcium concentration in monolayer-cultured human keratinocytes after physical or chemical stimulation (Tsutsumi et al, 2010b(Tsutsumi et al, , 2013. The (Nakatani et al, 2011), but the density of peripheral nerve fibers in healthy skin is quite low (Tsutsumi et al, 2016) and may be inadequate to provide such fine discrimination.…”