Mathematical analysis of oxygen and carbon dioxide exchange in the human capillary and tissue system

Lone, Ahsan Ul Haq; Khanday, M. A.

doi:10.1080/10255842.2022.2053115

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…In association with this fact several abnormalities may emerge putting the life of an individual at stake. The noteworthy of those conditions is hypoxia -the state of oxygen deficiency in the tissues [5,9,10,15,18]. Aerobic respiration, involving oxygen as the final electron acceptor, is extremely efficient than anaerobic respiration.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Study of Pulmonary and Intravenous Administration of Oxygen in Biological Tissues Under Hypoxia Conditions

Lone¹,

Khanday²,

Mubarak³

2022

SEAJMMS

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Mathematical modelling of oxygen transport in biological tissues played a great role and provides optimal results for advanced biomedical and biophysical research. Conventionally, oxygen is administered to hypoxic patients through pul- monary route. A mathematical model has been proposed to establish an alternative route for oxygen supply, whereby oxygen is administered directly into the target tis- sue bypassing the lung compartment. Our study aims at evaluating the feasibility of the novel approach using compartment modelling. The model is represented by a system of first order ordinary differential equations and their solution by Cramer’s rule and Laplace transform method. The concentration profiles of oxygen through pulmonary and intravenous routes were estimated in the arterial blood and tissue compartments at different flow rates; and with respect to initial oxygen concen- tration in the lung compartment and in the injected solution. Our results are in agreement with those arrived at by Lin Gui and Jing Liu (2006) [4]. The method offers a promising alternative to the conventional approach for clinical rescue of hypoxic patients, more so in emergency situations.

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Section: Introductionmentioning

confidence: 99%

Mathematical Study of Pulmonary and Intravenous Administration of Oxygen in Biological Tissues Under Hypoxia Conditions

Lone¹,

Khanday²,

Mubarak³

2022

SEAJMMS

View full text Add to dashboard Cite

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Cardiovascular System, Its Functions and Disorders

Rabadia,

Thite,

Desai

et al. 2024

Cardioprotective Plants

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Enhancing osteogenic differentiation of diabetic tendon stem/progenitor cells through hyperoxia: Unveiling ROS/HIF‐1α signalling axis

Zhang,

Dai,

Zhang

et al. 2024

J Cellular Molecular Medi

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Diabetic calcific tendinopathy is the leading cause of chronic pain, mobility restriction, and tendon rupture in patients with diabetes. Tendon stem/progenitor cells (TSPCs) have been implicated in the development of diabetic calcified tendinopathy, but the molecular mechanisms remain unclear. This study found that diabetic tendons have a hyperoxic environment, characterized by increased oxygen delivery channels and carriers. In hyperoxic environment, TSPCs showed enhanced osteogenic differentiation and increased levels of reactive oxygen species (ROS). Additionally, hypoxia‐inducible factor‐1a (HIF‐1a), a protein involved in regulating cellular responses to hyperoxia, was decreased in TSPCs by the ubiquitin‐proteasome system. By intervening with antioxidant N‐acetyl‐L‐cysteine (NAC) and overexpressing HIF‐1a, we discovered that blocking the ROS/HIF‐1a signalling axis significantly inhibited the osteogenic differentiation ability of TSPCs. Animal experiments further confirmed that hyperoxic environment could cause calcification in the Achilles tendon tissue of rats, while NAC intervention prevented calcification. These findings demonstrate that hyperoxia in diabetic tendons promotes osteogenic differentiation of TSPCs through the ROS/HIF‐1a signalling axis. This study provides a new theoretical basis and research target for preventing and treating diabetic calcified tendinopathy.

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Mathematical analysis of oxygen and carbon dioxide exchange in the human capillary and tissue system

Cited by 4 publications

References 15 publications

Mathematical Study of Pulmonary and Intravenous Administration of Oxygen in Biological Tissues Under Hypoxia Conditions

Mathematical Study of Pulmonary and Intravenous Administration of Oxygen in Biological Tissues Under Hypoxia Conditions

Cardiovascular System, Its Functions and Disorders

Enhancing osteogenic differentiation of diabetic tendon stem/progenitor cells through hyperoxia: Unveiling ROS/HIF‐1α signalling axis

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