Mathematical Analysis of oxygen Transport in the Retina

Seth, Deepti

doi:10.1109/icict46931.2019.8977711

Cited by 1 publication

(2 citation statements)

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“…An oxygen delivery term based on Fick's principle was included in layer 4 to model the delivery of oxygen from the arteries to the retinal tissue. Hence incorporating equation (7) with oxygen diffusion in equation ( 4) results in a transport equation (8).…”

Section: Computational Domainmentioning

confidence: 99%

“…However, laser treatments require a reduction in retinal cell oxygen consumption and may lead to retinal tissue degradation [7]. Seth et al [8] reported that extreme hyperoxia would be needed to make the choroid capable of supplying the whole retina during total retinal artery occlusion. However, this study is founded on the oxygen toxicity hypothesis that hyperoxia causes secondary photoreceptor loss, which results from the reduction in oxygen uptake following the initial loss of photoreceptors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Two-dimensional mathematical modelling of retinal oxygen transport and recommending treatment options

Aquah¹,

Kholi²,

Tulashie³

2021

Biomed. Phys. Eng. Express

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This paper presents a novel two-dimensional (2D) computational modeling of the retinal oxygen delivery, transport, and consumption analysis. The 2D modeling allows the division of the retina into four layers to address different flow profiles. The retina domain was meshed using the ICEM CFD mesher, while the ANSYS Fluent was used to calculate the transport phenomena for the four different layers. Clinical cases such as diabetes and sickle cell anaemia denoting the effects of decreasing retinal blood flow and hemoglobin's oxygen affinity were investigated. The simulation results showed that for a healthy retina in light and dark conditions, the outer retina is in danger of hypoxia at thickness >197.56 μm. However, the treatment of severe ischaemia using extreme hyperoxia seems beneficial for retinal thickness >197.56 μm but harmful for thickness <122.75 μm. The reduction of hemoglobin's oxygen affinity at low blood flow regimes could not improve the retina's oxygen levels. The study supports the oxygen toxicity hypothesis that hypoxia causes retina degeneration and estimates the retinal thickness and lighting conditions (dark or light) this may occur.

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Section: Computational Domainmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%