A sequential flow and solidification method was applied to the numerical investigation of flow control technology for grouting and blocking of flowing water in karst conduits. This method accounted for the temporal‐ and spatial‐evolution characteristics of the viscosity. It achieved the visualization of grouting in flowing water in a conduit, and was used to explore a reasonable and effective method for grouting through flow‐control technology. Firstly, the responses of different water tables and flow‐control intensities were studied by establishing a generalized model of flow control at the outlet of a conduit. Secondly, the initial sedimentation location and the distance of down‐flow and counter‐flow of slurries with different intensities of flow control were compared and analyzed. The outlet flow, the loss rate of the slurry, and the distribution laws of velocity and pressure inside the conduit during plugging were further analyzed. In addition, the mechanism of flow control for the grouting and plugging of large‐flow conduits was revealed. The results showed that the most direct effect of flow control on grouting was to decrease the flow rate of flowing water, and the most essential role was to improve the retention rate of slurry. Moreover, the results were applied to the large‐scale water inrush control project of Hejing Limestone Mine, China. The slurry stop devices improved the retention rate of slurry and optimized the grouting technology, which had a certain guiding significance in the treatment of water‐inrush disasters in karst areas.