Mathematical and Pharmacokinetic Approaches for the Design of New 3D Printing Inks Using Ricobendazole

Barberis, María Eugenia; Palma, Santiago Daniel; Gonzo, Elio Emilio; Bermúdez, José Marı́a Ancochea; Lorier, Marianela; Ibarra, Manuel; Real, Juan Pablo

doi:10.1007/s11095-022-03320-z

Cited by 10 publications

(4 citation statements)

References 34 publications

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“…A DOM nanosuspension (DOM-NS) was prepared by microsphere-assisted nanomilling using a laboratory-scale mill, NanoDisp ® (Córdoba, Argentina) [ 28 ]. The equipment consisted of a chamber where the milling material, zirconium beads of 0.1 mm diameter, and the suspension, formed by the drug and stabilizing agents, were housed.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, our work group has used the melt solidification printing process (MESO-PP) method to obtain fast-release oral SDFs loaded with 50% albendazole NCs, significantly improving the dissolution properties of this drug in the stomach. This direct extrusion technique is characterized by the absence of solvents, high temperatures and extreme pressures [ 26 , 27 , 28 , 29 , 30 ]—all of which could negatively affect the NCs and their distinctive characteristics. MESO-PP is so far the only method that has been able to load NCs in a SDF at such concentration.…”

Section: Introductionmentioning

confidence: 99%

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Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

et al. 2023

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Domperidone (DOM) is a drug commonly used to treat nausea and vomiting, as well as gastrointestinal disorders. However, its low solubility and extensive metabolism pose significant administration challenges. In this study, we aimed to improve DOM solubility and avoid its metabolism by developing nanocrystals (NC) of DOM through a 3D printing technology—melting solidification printing process (MESO-PP)—to be delivered via a solid dosage form (SDF) that can be administered sublingually. We obtained DOM-NCs using the wet milling process and designed an ultra-rapid release ink (composed of PEG 1500, propylene glycol, sodium starch glycolate, croscarmellose sodium, and sodium citrate) for the 3D printing process. The results demonstrated an increase in the saturation solubility of DOM in both water and simulated saliva without any physicochemical changes in the ink as observed by DSC, TGA, DRX, and FT-IR. The combination of nanotechnology and 3D printing technology enabled us to produce a rapidly disintegrating SDF with an improved drug-release profile. This study demonstrates the potential of developing sublingual dosage forms for drugs with low aqueous solubility using nanotechnology and 3D printing technology, providing a feasible solution to the challenges associated with the administration of drugs with low solubility and extensive metabolism in pharmacology.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

et al. 2023

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“…Recently, mathematical adaptations were employed to develop drug-loaded formulations to facilitate an optimized polymer and drug wt. percentages for a tailored drug release ( 12 ). Antibiotics are key for treating bacterial infections.…”

Section: Types Of 3d Printingmentioning

confidence: 99%

3D printing of pharmaceuticals for disease treatment

Chakka

Chede

2023

Front. Med. Technol.

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Three-dimensional (3D) printing or Additive manufacturing has paved the way for developing and manufacturing pharmaceuticals in a personalized manner for patients with high volume and rare diseases. The traditional pharmaceutical manufacturing process involves the utilization of various excipients to facilitate the stages of blending, mixing, pressing, releasing, and packaging. In some cases, these excipients cause serious side effects to the patients. The 3D printing of pharmaceutical manufacturing avoids the need for excessive excipients. The two major components of a 3D printed tablet or dosage form are polymer matrix and drug component alone. Hence the usage of the 3D printed dosage forms for disease treatment will avoid unwanted side effects and provide higher therapeutic efficacy. With respect to the benefits of the 3D printed pharmaceuticals, the present review was constructed by discussing the role of 3D printing in producing formulations of various dosage forms such as fast and slow releasing, buccal delivery, and localized delivery. The dosage forms are polymeric tablets, nanoparticles, scaffolds, and films employed for treating different diseases.

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“…To overcome these challenges, in previous works, our group has incorporated albendazole NCRs in solid pharmaceutical forms loaded up to 50% [32], using the 3D printing method, patented by the University of Cordoba, MESO-PP (an acronym for melting solidification printing process) [33]. This method, based on the extrusion of semi-solids by syringe of materials that melt in the range of 40 to 60 • C, allows not only to load of high percentages of NC without using extreme forces but also has advantages inherent to 3D printing, such as (a) creating geometries that are not achievable by traditional methods, such as hollow or porous structures that allow solids to float [34,35], and (b) modulating release rates using different carrier materials, such as Gelucire (fatty polyethylene glycol esters) [36].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Gastroretentive Tablets Loaded with Niclosamide Nanocrystals by the Melting Solidification Printing Process (MESO-PP)

Real

Lopez-Vidal

et al. 2023

Pharmaceutics

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Niclosamide (NICLO) is a recognized antiparasitic drug being repositioned for Helicobacter pylori. The present work aimed to formulate NICLO nanocrystals (NICLO-NCRs) to produce a higher dissolution rate of the active ingredient and to incorporate these nanosystems into a floating solid dosage form to release them into the stomach slowly. For this purpose, NICLO-NCRs were produced by wet-milling and included in a floating Gelucire l3D printed tablet by semi-solid extrusion, applying the Melting solidification printing process (MESO-PP) methodology. The results obtained in TGA, DSC, XRD and FT-IR analysis showed no physicochemical interactions or modifications in the crystallinity of NICLO-NCR after inclusion in Gelucire 50/13 ink. This method allowed the incorporation of NICLO-NCRs in a concentration of up to 25% w/w. It achieved a controlled release of NCRs in a simulated gastric medium. Moreover, the presence of NICLO-NCRs after redispersion of the printlets was observed by STEM. Additionally, no effects on the cell viability of the NCRs were demonstrated in the GES-1 cell line. Finally, gastroretention was demonstrated for 180 min in dogs. These findings show the potential of the MESO-PP technique in obtaining slow-release gastro-retentive oral solid dosage forms loaded with nanocrystals of a poorly soluble drug, an ideal system for treating gastric pathologies such as H. pylori.

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Mathematical and Pharmacokinetic Approaches for the Design of New 3D Printing Inks Using Ricobendazole

Cited by 10 publications

References 34 publications

Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

3D printing of pharmaceuticals for disease treatment

3D-Printed Gastroretentive Tablets Loaded with Niclosamide Nanocrystals by the Melting Solidification Printing Process (MESO-PP)

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