Recent publications call for a higher focus on implementation of the theoretical concept of industrial ecology. It embodies the idea that collaborating companies use each other's waste and byproducts following the example of the natural metabolism. Subject matter of this work is the practical application of this idea, i.e. eco-industrial parks and networks. In addition to the positive impact on the environment due to a reduction of pressure on limited natural resources, existing cases show that benefits can simultaneously be achieved for all three dimensions of sustainable development, including the economy and society. In order to promote this concept and thus facilitate the implementation of sustainable development in the private sector, this thesis proposes an Interactive Optimized Negotiation Algorithm (IONA) embedding a mixed-integer linear program with weighted achievement functions. This flexible network model supports the establishment of new industrial ecology in practice. It can flexibly be adapted to various circumstances and overcomes major critiques of existing approaches. In addition to the computer implementation of this advanced modeling approach, this work provides a catalogue of requirements to meet when modeling industrial ecology. The approach considers multiple objectives, different stakeholder interests, and various material flow types. The closing study of two cases shows the comprehensive capabilities of the program. Exceeding the scope of this work, the computer program can be used to conduct studies of existing networks regarding their stability when facing today's increasing necessity to set and meet environmental and social objectives. iii ACKNOWLEDGMENTS Foremost, I would like to express my sincere gratitude to my advisor Dr. Manbir Sodhi for the continuous support of my research, for his patience, motivation, enthusiasm, and immense knowledge. His guidance helped me in all the time of research and writing of this thesis. Besides my advisor, I thank Dr. David Taggart, Dr. Mercedes A. Rivero-Hudec, and Dr. Vinka Craver, for their encouragement and insightful comments. My sincere thanks also go to Prof. Dr. Thomas Spengler, who supported me over the long distance from Technische Universität Braunschweig, Germany and on location of my research with inspirational discussion and comments in both my professional career and personal life. A special acknowledgement goes to Rene Minnocci. Her dedicative support, encouragement, and effort in my personal life and for this thesis were an enduring source of energy and of great value to the outcome of this research project. You are an amazing person and important part of my life. Last but not the least, I would like to thank my whole family. I particularly thank, my parents Marion and Hans-Jürgen Schulze as well as my brother Marco Schulze for their constant support. Without their enduring love and care in every situation of my life I could not have gone this path and reached the point where I am today. I cherish every moment of my life thanks to y...