Mathematical description of synergistic interaction of UV light and hyperthermia for yeast cells

Петин, В.Г.; Kim, Jin Kyu; Zhurakovskaya, Galina P.; Rassokhina, Anastasiya V

doi:10.1016/s1011-1344(00)00035-x

Cited by 14 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The synergistic interaction of UV light and hyperthermia is expected to result in additional damage due to the interaction of some sub-lesions induced by both agents (Petin et al, 2000(Petin et al, , 1997Tyrrell, 1976). Lower temperatures during UV-B radiation will result in a decrease of synergism (Petin et al, 1997), therefore, causing less damage in the cells.…”

Section: Resultsmentioning

confidence: 99%

Cold activity and tolerance of the entomopathogenic fungus Tolypocladium spp. to UV-B irradiation and heat

Santos

Dias

Ferreira

et al. 2011

Journal of Invertebrate Pathology

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Cold activity and tolerance of the entomopathogenic fungus Tolypocladium spp. to UV-B irradiation and heat

Santos

Dias

Ferreira

et al. 2011

Journal of Invertebrate Pathology

View full text Add to dashboard Cite

“…To interpret the results obtained in this study, a simple mathematical model of the synergistic interaction for lethal effects produced by a simultaneous combined action of UV radiation and hyperthermia (16) may be engaged. The model suggests that the synergistic interaction of UV light and hyperthermia is expected to result from some additional lethal damages arising from the interaction of some sublesions induced by both agents.…”

Section: Discussionmentioning

confidence: 99%

“…These sublesions are considered ineffective when each agent is taken alone. One of the main conclusions of this model is the dependence of the synergistic effect on the ratio of lethal damages ( N 2 /N 1 ) produced by UV light (N 1 ) and hyperthermia ( N 2 ) applied alone (16). In accordance with the model's consequences, within a definite range of N 2 /N 1 , the synergistic enhancement ratio increases, reaches its highest value and then decreases with the N 2 /N 1 increasing.…”

Section: Discussionmentioning

confidence: 99%

“…Error bars in all figures show interexperimental errors. Other details were as described previously (15,16,20,22).…”

Section: Methodsmentioning

confidence: 99%

“…The decrease in the dose rate of the ionizing radiation required a decrease in the temperature at which the irradiation was carried out to preserve a definite effect of a simultaneous thermoradiation action on T4 bacteriophage (10), dry Bacillus subtilis spores (11), attenuated poliovirus (12), mammalian (13) and yeast (14) cells. In earlier investigations of yeast cell inactivation by a simultaneous treatment with UV light and hyperthermia (15,16), the correlation between the optimal temperature that maximized the synergy and the UV light fluence rate was estimated: this temperature shifted towards the lower temperature values with a decreasing fluence rate. However all the above mentioned results supporting this conclusion were obtained for the inactivation of various unicellular organisms.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Fluence Rate Determines the Synergistic Interaction of UV Radiation and Heat for Mitotic Recombination and Cell Inactivation in Yeasts

Kim

Komarova

Zhurakovskaya

et al. 2006

Photochem & Photobiology

Self Cite

View full text Add to dashboard Cite

The significance of the UV fluence rate for the synergistic interaction of UV light (254 nm) and heat was demonstrated for the frequency of mitotic recombination in a wild-type diploid yeast of Saccharomyces cerevisiae (strain T1) and for cell inactivation of two wild-type diploid yeast of S. cerevisiae (strains T1, XS800). It was shown for mitotic recombination that a decrease in the intensity of UV exposure results in the necessity of decreasing the temperature at which UV irradiation occurs to provide the same value of the synergistic enhancement ratio. For cell inactivation, there was a specific temperature maximizing the synergistic effect for any constant fluence rate and the temperature range, synergistically increasing the inactivation effect of UV radiation, should be shifted to lower temperatures with a decrease in the fluence rate. To interpret the results observed, a simple mathematical model of the synergistic interaction was applied. The model suggests that the synergistic interaction of UV light and hyperthermia is expected to result from some additional effective damages arising from the interaction of some sublesions induced by both agents. On the basis of data obtained, it was supposed that the synergistic interaction of these factors might take place at small intensities of UV light and temperatures existing in the biosphere. In other words, for a long duration of interaction, which is important for problems of UV light protection and health effects, one can expect a synergistic interaction of this factor with environmental heat or physiological temperatures and thereby an increase in their inactivating and genetic consequences.

show abstract

Current Awareness

2000

Yeast

View full text Add to dashboard Cite

Mathematical description of synergistic interaction of UV light and hyperthermia for yeast cells

Cited by 14 publications

References 12 publications

Cold activity and tolerance of the entomopathogenic fungus Tolypocladium spp. to UV-B irradiation and heat

Cold activity and tolerance of the entomopathogenic fungus Tolypocladium spp. to UV-B irradiation and heat

The Fluence Rate Determines the Synergistic Interaction of UV Radiation and Heat for Mitotic Recombination and Cell Inactivation in Yeasts

Current Awareness

Contact Info

Product

Resources

About