Mathematical model of mass transport through dispersed‐phase polymer networks

Varelas, C. G.; Dixon, David G.; Steiner, Carol A.

doi:10.1002/aic.690410407

Cited by 18 publications

(11 citation statements)

References 5 publications

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“…Again, a strongly heterogeneous structure of modified alginate gels can be proposed in order to explain this peculiar behavior; hydrophobic microdomains are likely to offer distinct features in terms of solute partition and diffusion, compared to the hydrophilic phase. Depending on the volume fraction and specificities of these dispersed domains, complex release kinetics, far away from the classical Fickian predictions, can result [44]. It is worth noting that such a strategy, based on defined heterogeneous matrices including hydrophilic and hydrophobic domains, has been already proposed in order to tune controlled release situations and achieve zero-order kinetics [45].…”

Section: Properties Of Hydrogel Particlesmentioning

confidence: 97%

Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: Bead formation, structure, and stability

Boisseson¹,

Léonard²,

Hubert³

et al. 2004

Journal of Colloid and Interface Science

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Section: Properties Of Hydrogel Particlesmentioning

confidence: 97%

Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: Bead formation, structure, and stability

Boisseson¹,

Léonard²,

Hubert³

et al. 2004

Journal of Colloid and Interface Science

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“…[125][126][127][128][129][130][131][132] In addition, the cellular mechanism of solute transport is sufficiently well understood as to the absorption of various drugs, so that there is now the possibility of targeting drugs to outside or inside the cell of a particular locatin by use of ligand-receptor interactions. 71,81,133 Unfortunately it is not yet possible to design a bioadhesive based on specific structural features of a polymer.…”

Section: Next Generationmentioning

confidence: 99%

Bioadhesive‐Based Dosage Forms: The Next Generation

Lee

Park

Robinson

2000

Journal of Pharmaceutical Sciences

469

152

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“…A nonhomogeneous distribution of drug is accounted for in a drug-release model proposed by Varelas et al, but the polymer matrix does not erode. 28,29 In this model, isolated domains act as reservoirs from which drug diffuses through a polymer matrix. We have developed a model for erosion and drug release that accounts for microphase-separated domains that erode at different rates and for partitioning of encapsulated drugs within the phase-separated domains.…”

Section: Introductionmentioning

confidence: 99%

Molecular Description of Erosion Phenomena in Biodegradable Polymers

Kipper

Narasimhan

2005

Macromolecules

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A new model for the erosion kinetics of semicrystalline surface-erodible homopolymers and copolymers is presented. The model is derived for a class of surface-erodible polyanhydride copolymers, with the goal of describing erosion in terms of fundamental, elementary processes. This model is based on an accurate description of copolymer microstructure and can thereby account for the heterogeneous erosion due to microphase separation and crystallinity. In addition to accurately predicting the overall erosion profile and the release of individual monomer species, several key phenomena that occur during erosion are described. These include precipitation of slightly soluble degradation products inside the pores of the erosion zone and pH changes during erosion due to dissolution of acidic monomers and the consequent changes in monomer solubility. This model also motivates future experiments to investigate predicted phenomena such as the effects due to local changes in pH and degradation rate constants for crystalline and amorphous moieties. The rational design of biomedical devices such as vehicles for drug delivery and scaffolds for tissue engineering will be aided by the application of this model and future extensions of it. Received November 13, 2004; Revised Manuscript Received December 13, 2004 ABSTRACT: A new model for the erosion kinetics of semicrystalline surface-erodible homopolymers and copolymers is presented. The model is derived for a class of surface-erodible polyanhydride copolymers, with the goal of describing erosion in terms of fundamental, elementary processes. This model is based on an accurate description of copolymer microstructure and can thereby account for the heterogeneous erosion due to microphase separation and crystallinity. In addition to accurately predicting the overall erosion profile and the release of individual monomer species, several key phenomena that occur during erosion are described. These include precipitation of slightly soluble degradation products inside the pores of the erosion zone and pH changes during erosion due to dissolution of acidic monomers and the consequent changes in monomer solubility. This model also motivates future experiments to investigate predicted phenomena such as the effects due to local changes in pH and degradation rate constants for crystalline and amorphous moieties. The rational design of biomedical devices such as vehicles for drug delivery and scaffolds for tissue engineering will be aided by the application of this model and future extensions of it.

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Mathematical model of mass transport through dispersed‐phase polymer networks

Cited by 18 publications

References 5 publications

Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: Bead formation, structure, and stability

Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: Bead formation, structure, and stability

Bioadhesive‐Based Dosage Forms: The Next Generation

Molecular Description of Erosion Phenomena in Biodegradable Polymers

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