Mathematical model of the germ cells’ mechanoreception

Zhdankina, Yuliya S.

doi:10.1063/5.0035746

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…We have measured the stiffness of various cells and, based on them, proposed a mathematical model and calculated the magnitude of the deformation when the force of gravity changes by 1 g (for example, from 1 g to 0 g, or in the opposite direction) [ 113 , 115 , 116 , 117 , 118 , 119 ]. The results of mathematical modeling and comparison with experimental data indicate that such deformation energy is sufficient for dissociation, for example, from actin filaments of actin-binding proteins.…”

Section: Mechanoreception and Mechanotransduction In The Cellmentioning

confidence: 99%

Single Cell in a Gravity Field

Ogneva

2022

Life

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The exploration of deep space or other bodies of the solar system, associated with a long stay in microgravity or altered gravity, requires the development of fundamentally new methods of protecting the human body. Most of the negative changes in micro- or hypergravity occur at the cellular level; however, the mechanism of reception of the altered gravity and transduction of this signal, leading to the formation of an adaptive pattern of the cell, is still poorly understood. At the same time, most of the negative changes that occur in early embryos when the force of gravity changes almost disappear by the time the new organism is born. This review is devoted to the responses of early embryos and stem cells, as well as terminally differentiated germ cells, to changes in gravity. An attempt was made to generalize the data presented in the literature and propose a possible unified mechanism for the reception by a single cell of an increase and decrease in gravity based on various deformations of the cortical cytoskeleton.

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Section: Mechanoreception and Mechanotransduction In The Cellmentioning

confidence: 99%

Single Cell in a Gravity Field

Ogneva

2022

Life

View full text Add to dashboard Cite

show abstract

Mathematical model of the germ cells’ mechanoreception

Cited by 1 publication

References 24 publications

Single Cell in a Gravity Field

Single Cell in a Gravity Field

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