Mathematical Modeling of Anti-Tumor Vaccinotherapy: The Interaction of Immune System with Tumor Cells

Kuzina, Ekaterina A.; Babushkina, N. A.

doi:10.1109/mlsd.2019.8911002

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2021

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“…We propose a model that joins these previously mentioned models, taking into account both cancer cell differentiation and the most important cells of the immune system. Impulsive functions will be added to stimulate the cells of the immune system to analyse the response of the CSCs and/or the differentiated cancer cells [23,43].…”

Section: Methodsmentioning

confidence: 99%

An integrative model of cancer cell differentiation with immunotherapy^*

Margarit¹,

González²,

Romanelli³

et al. 2021

Phys. Biol.

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In order to improve cancer treatments, cancer cell differentiation and immunotherapy are the subjects of several studies in different branches of interdisciplinary sciences. In this work, we develop a new population model that integrates other complementary ones, thus emphasizing the relationship between cancer cells at different differentiation stages and the main immune system cells. For this new system, specific ranges were found where transdifferentiation of differentiated cancer cells can occur. In addition, a specific therapy against cancer stem cells was analysed by simulating cytotoxic cell vaccines. In reference to the latter, the different combinations of parameters that optimize it were studied.

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Section: Methodsmentioning

confidence: 99%