Mathematical modeling of degradation for bulk-erosive polymers: Applications in tissue engineering scaffolds and drug delivery systems

Chen, Yuhang; Zhou, Shiwei; Li, Qing

doi:10.1016/j.actbio.2010.09.038

Cited by 140 publications

(105 citation statements)

References 51 publications

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“…Reaction-diffusion models have been applied to a range of aliphatic polyesters. Among these models, the ones which account for the autocatalytic effect are the most comprehensive, as autocatalysis plays a strong role in the degradation mechanism (Chen et al, 2011;Ford Versypt et al, 2013;Wang et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Shirazi

Ronan

Rochev

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Publication InformationShirazi, RN,Ronan, W,Rochev, Y,McHugh, P (2016) 'Modelling the degradation and elastic properties of poly (lacticco-glycolic AbstractScaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational investigation of the molecular weight degradation and the mechanical performance of poly(lactic-co-glycolic acid) (PLGA) films and tissue engineering scaffolds. A reactiondiffusion model which predicts the degradation behaviour is coupled with an entropy-based mechanical model which relates the Young's modulus and the molecular weight. The model parameters are determined based on experimental data for in-vitro degradation of a PLGA film. Microstructural models of three different scaffold architectures are used to investigate the degradation and mechanical behaviour of each scaffold. Although the architecture of the scaffold does not have a significant influence on the degradation rate, it determines the initial stiffness of the scaffold. It is revealed that the size of the scaffold strut controls the degradation rate and the mechanical collapse. A critical length scale due to competition between diffusion of degradation products and autocatalytic degradation is determined to be in the range 2-100 μm. Below this range, slower homogenous degradation occurs; however, for larger samples monomers are trapped inside the sample and faster autocatalytic degradation occurs.

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Section: Introductionmentioning

confidence: 99%

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Shirazi

Ronan

Rochev

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…Computational modelling has been used in an effort to provide insightful interpretation of experimental results [13][14][15][16] and can be very useful when attempting to quantify the thickness dependence of degradation. Reaction-diffusion models have been developed and have significant potential to assess and predict the rate of degradation and to aid the design of biodegradable devices [17].…”

Section: Introductionmentioning

confidence: 99%

Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance

Shirazi

Aldabbagh

Ronan

et al. 2016

J Mater Sci: Mater Med

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(2016). Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance. Journal of Materials Science: Materials in Medicine, 27(10), 1-12. doi: 10.1007/s10856-016-5760-z PublisherSpringer Verlag The specific material processing methods considered here did not have a significant effect on the degradation rate and the changes in mechanical properties during degradation; however, they influenced the initial molecular weight and they determined the stiffness and hardness of the PLGA material. The experimental observations strongly supported the computational modelling predictions that showed no significant difference in the degradation rate and the changes in the elastic modulus of PLGA films for thicknesses larger than 100 μm.

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“…Chemical breakdown and polymer erosion happen through the process of hydrolysis, and salivary fluid may play a role in the process here. [22,27].…”

Section: Weight Lossmentioning

confidence: 99%

Chitosan-gelatine membrane construct with different cinnamaldehyde concentration as drug delivery system in oral cavity

Ridwan¹,

Purwanti²,

Yulianto³

et al. 2016

AIP Conference Proceedings

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Abstract. The aim of the present study was to develop the chitosan-gelatin membrane for cinnamaldehyde control release since it has a crosslinking effect. Porous membranes with differences cinnamaldehyde concentration as an antiinflammatory agent in the size of ±1.5x1.5 cm, 1 mm thickness and weight around 0.27 g were prepared for measure the swelling ratio and weight loss. Scanning electron microscopy was carried out to describe the surface structure, and the chemical bonding was investigated by Fourier Transformed Infrared (F-TIR). The one way ANOVA and LSD analysis of the swelling ratio and weight loss demonstrated that there were significant differences between all cinnamaldehyde groups and a control group (p<0.05).

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Mathematical modeling of degradation for bulk-erosive polymers: Applications in tissue engineering scaffolds and drug delivery systems

Cited by 140 publications

References 51 publications

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open-cell tissue engineering scaffolds

Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance

Chitosan-gelatine membrane construct with different cinnamaldehyde concentration as drug delivery system in oral cavity

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