Mathematical Modeling of Human Cortical Spreading Depression

Computational modeling of neurostimulation in brain diseases

“…The success of computational models of CSD is especially highlighted in their application to understand disease pathology and mechanisms. For example, Dahlem (2013b) and Dahlem (2016) demonstrate that complex propagation patterns of CSD can arise on the folded cortex, which was confirmed recently by experiments (Santos et al, 2014). The strength of predicting such patterns is that these could be related to the different types of migraine: migraines with aura only; migraine with aura and headache; and migraines without aura but with headaches (see Fig.…”