Energy storage units (ESU) and distributed generation (DG) plants including those using renewable energy sources can be used to develop isolated power supply systems (IPSS) and enhance their reliability. Operation of DG plants in the IPSS requires to consider restrictions for consumers maximum load, as well as effects of abrupt load increase or load shedding on the generating plants. These problems can be resolved using ESU and intelligent technologies for DG plants control. The paper considers IPSS of an industrial facility with turbogenerator plants (TGP), wind power plant (WPP) and high-capacity ESU for which fuzzy control systems and prognostic controllers were used. The simulation was performed in the MATLAB system using the Simulink and SimPowerSystems software packages. Normal and emergency modes were studied in IPSS with TGP, WPP, and high-capacity ESU. The simulation results indicated that combined use of high-capacity ESU and prognostic controller of TGP generator rotor speed allows to ensure stability and survivability of IPSS enhancing its damping properties. The auto-prognostic controller of the TGP generator, which does not require special adjustment, provides high quality indicators of the IPSS control in all considered modes.