2024
DOI: 10.1101/2024.01.09.574774
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Mathematical modeling of the influence ofACE I/Dpolymorphism on blood pressure and antihypertensive therapy

Elena Kutumova,
Anna Kovaleva,
Ruslan Sharipov
et al.

Abstract: The angiotensin converting enzyme (ACE) gene (ACE) insertion/deletion (I/D) polymorphism has attracted much attention in recent years, as it raises the hope of personalizing ACE inhibitor therapy to optimize its efficiency and reduce side effects for genetically distinct subgroups. However, the extent of its influence among these subgroups remains inconclusive. Therefore, we extended our computational model of blood pressure regulation to investigate the effect of theACE I/Dpolymorphism on hemodynamic paramete… Show more

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