Mathematical Modeling of Thermal Damage Estimate Volumes in MR‐guided Laser Interstitial Thermal Therapy

Liang, Allison; Munier, Sean M; Danish, Shabbar F.

doi:10.1111/jon.12830

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…In previous literature, the characteristics of 980 nm and 1,064 nm laser wavelengths applied in clinical surgical procedures have been contrasted (6,(10)(11)(12)(13)(14). The 980 nm (wavelength) laser is often used and has been well-studied in LITT (15)(16)(17)(18)(19); it can produce rapid and localized heating of tissues, thereby causing lesions with distinct borders while using relatively low power (9). The 980 nm laser offers advantages such as concentrated energy, faster heating rates, and clearer boundaries.…”

Section: Introductionmentioning

confidence: 99%

Modeling and in vivo experimental validation of 1,064 nm laser interstitial thermal therapy on brain tissue

Cao,

Shi,

et al. 2023

Front. Neurol.

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IntroductionLaser interstitial thermal therapy (LITT) at 1064 nm is widely used to treat epilepsy and brain tumors; however, no numerical model exists that can predict the ablation region with careful in vivo validation.MethodsIn this study, we proposed a model with a system of finite element methods simulating heat transfer inside the brain tissue, radiative transfer from the applicator into the brain tissue, and a model for tissue damage.ResultsTo speed up the computation for practical applications, we also validated P1-approximation as an efficient and fast method for calculating radiative transfer by comparing it with Monte Carlo simulation. Finally, we validated the proposed numerical model in vivo on six healthy canines and eight human patients with epilepsy and found strong agreement between the predicted temperature profile and ablation area and the magnetic resonance imaging-measured results.DiscussionOur results demonstrate the feasibility and reliability of the model in predicting the ablation area of 1,064 nm LITT, which is important for presurgical planning when using LITT.

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Section: Introductionmentioning

confidence: 99%

Modeling and in vivo experimental validation of 1,064 nm laser interstitial thermal therapy on brain tissue

Cao,

Shi,

et al. 2023

Front. Neurol.

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The Impact of Perilesional Heatsink Structures on Ablation Volumes in Laser Interstitial Thermal Therapy for Brain Metastases

Bhatia,

Berke,

Rivera

et al. 2024

Neurosurgery

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BACKGROUND AND OBJECTIVES: Laser interstitial thermal therapy (LITT) has demonstrated promise in surgical neuro-oncology because of its effectiveness in delivering precise thermal energy to lesions. The extent of ablation (EOA) is a prognostic factor in improving patient outcomes but is often affected by perilesional heatsink structures, which can lead to asymmetric ablations. The purpose of this study was to quantitatively evaluate the impact of various perilesional heatsink structures on the EOA in LITT for brain metastases. METHODS: Twenty-seven procedures for 22 unique patients with brain metastases fit the inclusion criteria. Intracranial heatsink structures were identified: sulci, meninges, cerebrospinal fluid (CSF) spaces, and vasculature. Asymmetric ablation was determined by measuring 3 pairs of orthogonal distances from the proximal, midpoint, and distal locations along the laser catheter to the farthest edge of the ablation zone bilaterally. Distances from the same points on the laser catheter to the nearest heatsink were also recorded. The Heatsink Effect Index was created to serve as a proxy for asymmetric ablation. Pearson correlations, t-tests, and analysis of variance were the statistical analyses performed. RESULTS: From the midpoint of the catheter, the 27 heatsinks were meninges (40.7%), sulci (22.2%), vasculature (22.2%), and CSF spaces (14.8%). Across all points along the catheter track, there was a significant generalized heatsink effect on asymmetric ablations (P < .0001). There was a negative correlation observed between asymmetric ablations and EOA from the midpoint of the laser catheter (r = −0.445, P = .020). Compared with sulci, CSF spaces trended toward a greater effect on asymmetric ablation volumes (P = .069). CONCLUSION: This novel quantitative analysis shows that perilesional heatsinks contribute to asymmetric ablations. CSF spaces trended toward higher degrees of asymmetric ablations. Importantly, neurosurgeons may anticipate asymmetric ablations preoperatively if heatsinks are located within 13.3 mm of the laser probe midpoint. These preliminary results may guide surgical decision-making in LITT for metastatic brain lesions.

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Mathematical Modeling of Thermal Damage Estimate Volumes in MR‐guided Laser Interstitial Thermal Therapy

Cited by 2 publications

References 25 publications

Modeling and in vivo experimental validation of 1,064 nm laser interstitial thermal therapy on brain tissue

Modeling and in vivo experimental validation of 1,064 nm laser interstitial thermal therapy on brain tissue

The Impact of Perilesional Heatsink Structures on Ablation Volumes in Laser Interstitial Thermal Therapy for Brain Metastases

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