Anaerobic Digestion (AD) is a well-established process that is becoming increasingly popular, especially as a technology for organic waste treatment; the process produces biogas, which can be upgraded to biomethane, which can be used in the transport sector or injected into the natural gas grid. Considering the sensitivity of Anaerobic Digestion to several process parameters, mathematical modeling and numerical simulations can be useful to improve both design and control of the process. Therefore, several different modeling approaches were presented in the literature, aiming at providing suitable tools for the design and simulation of these systems. The purpose of this study is to analyze the recent advancements in the biomethane production from different points of view. Special attention is paid to the integration of this technology with additional renewable energy sources, such as solar, geothermal and wind, aimed at achieving a fully renewable biomethane production. In this case, auxiliary heat may be provided by solar thermal or geothermal energy, while wind or photovoltaic plants can provide auxiliary electricity. Recent advancements in plants design, biomethane production and mathematical modeling are shown in the paper, and the main challenges that these fields must face with are discussed. Considering the increasing interest of industries, public policy makers and researchers in this field, the efficiency and profitability such hybrid renewable solutions for biomethane production are expected to significantly improve in the next future, provided that suitable subsidies and funding policies are implemented to support their development.