Mathematical models in drug delivery: How modeling has shaped the way we design new drug delivery systems

Peppas, Nicholas A.; Narasimhan, Balaji

doi:10.1016/j.jconrel.2014.06.041

Cited by 465 publications

(319 citation statements)

References 90 publications

Supporting

Mentioning

298

Contrasting

Unclassified

Order By: Relevance

“…Consequently, mathematical modeling of drug release processes from polymeric matrices plays an important role to predict the behavior of the system and to determine the structural parameters of the polymer that affect and control the drug release profiles. The drug release can occur through a pure Fickian diffusion, by processes of relaxation and sometimes a combination of these two mechanisms takes place [42] . When the semi-empirical equation of Ritger-Peppas, [43] , is used for fitting the experimental data, the diffusional exponent (n) indicates the mechanism for drug transport.…”

Section: Resultsmentioning

confidence: 99%

Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

et al. 2016

View full text Add to dashboard Cite

SbstractOxaliplatin was inserted into polymeric matrices aiming to study the interaction of this drug with these polymers and its capability to diffuse to the environment. Tested polymers were: (1) polyethylene glycol (PEG), (2) poly(lactic-co-glycolic acid) (PLGA), and (3) a copolymer of them (PLGA-PEG). The latter two were synthesized by us using polycondensation in bulk. Oxaliplatin was included in the matrices by the melt mixing process followed by casting. Fourier tran sform infrared spectroscopy (FTIR), proton nuclear magnetic resonance ( 1 H-NMR) and X-ray diffraction (DRX) studies of the polymers were performed proving the obtaining of the desired materials. In addition, the interaction between drug and matrices and the release profile of the oxaliplatin from these matrices were analyzed. Among them, PEG did not control the oxaliplatin release. In turn, PLGA and PLGA-PEG present drug release profiles quite similar. Oxaliplatin was completely released from PLGA and PLGA-PEG in 5 hours, by a relaxation mechanism. There was no evidence of oxaliplatin interaction with the different polymers. In addition, as the PEG improves the biocompatibility and biomasking, obtained results prove the obtaining of a drug release system, which allowed the total use of the drug improving the cancer treatment and even the welfare of the patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

et al. 2016

View full text Add to dashboard Cite

show abstract

“…S6 in the supplementary material). The tested models are: Higuchi [34], Korsmeyer-Peppas [35][36][37][38][39], and Weibull [40,41]. These models share a similar mathematical form: (i) the released amount of drug is described as the ratio between the cumulative amount of drug released at time t, M t , and infinite time, M ∞ ; (ii) time is scaled by a factor k; (iii) dependency on time is defined according to a power law.…”

Section: Resultsmentioning

confidence: 99%

Pluronic/gelatin composites for controlled release of actives

Tatini

Tempesti

Ridi

et al. 2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

“…(3), Table 4) [31,32]. The Korsmeyer-Peppas model provides information on the diffusion of the drugs within the gel matrices.…”

Section: -4 Mechanical Propertiesmentioning

confidence: 99%

Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Sagiri

Kasiviswanathan

Shaw

et al. 2016

Korean J. Chem. Eng.

View full text Add to dashboard Cite

The current study describes the effect of the concentration of Span 60 (gelator) on the properties of oleogels. Mustard oil was chosen as the representative vegetable oil. Microscopy showed that an increase in the gelator concentration resulted in the increase in the gelator network density. Thermal studies (crystallization kinetics and differential scanning calorimetry) indicated a 2-stage crystallization process. An increase in the gelator proportion resulted in the increase in the compatibility amongst the oleogel components. The formation of gelator network was governed by the interaction amongst the hydroxyl groups of Span 60. A variation in the gelator proportion resulted in the alteration in the d-spacing, crystallite size and lattice strain. The variation in the above-mentioned properties was found to affect the viscoelastic properties of the oleogels as was predicted from the Weichert model. The drug release studies suggested that the drug diffusion due to the gelator network relaxation during drug release was predominant as compared to the Fickian diffusion. The results suggested that it is possible to alter not only the release profile of drugs but also the physical properties (of the oleogels) by tailoring the gelator concentration.

show abstract

Mathematical models in drug delivery: How modeling has shaped the way we design new drug delivery systems

Cited by 465 publications

References 90 publications

Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

Pluronic/gelatin composites for controlled release of actives

Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Contact Info

Product

Resources

About