The use of internet as a media and source of learning at this time is very massive. Millennial generation is required to have digital literacy, so that they need for habituation in learning. Edmodo application that can be access by android, computer and tablet, can be used as a media in m-learning-based lectures. The study was done to find the impact of learning science with and without using Edmodo. The method used was quasi-experiment with non-equivalent control group design. Research subject were prospective primary school teachers of semester 6 year 2016/2017 from the department of primary school education -Universitas Pasundan Bandung. The subjects were divided into 41 students of experimental class (A) and 41 students of control class (B). Based on statistics calculations, the tcount = 4.790 > ttable (1.664), then H0 is rejected and H1 is accepted. This is means that the application of Edmodo as media learning is more effective to improve learning outcomes compared with control class that only using power point media. The results of this study indicate that students who have learned science with Edmodo show the better achievement than the student in control class. By the result, lecturer should be more creative to engage technology specifically based on android as media and source of learning science.