2015
DOI: 10.1534/genetics.115.176313
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Mating and Memory: An Educational Primer for Use with “Epigenetic Control of Learning and Memory in Drosophila by Tip60 HAT Action”

Abstract: SUMMARY An article by Xu et al. in the December 2014 issue of GENETICS can be used to illustrate epigenetic modification of gene expression, reverse genetic manipulation, genetic/epigenetic influence on behavioral studies, and studies using the Drosophila model organism applied to human disease. This Primer provides background information; technical explanations of genetic, biochemical, and behavioral approaches from the study; and an example of an approach for classroom use with discussion questions to aid in… Show more

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Cited by 3 publications
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“…Post-mortem studies performed on PD patients revealed that due to the formation of Lewy bodies in the olfactory bulb and in other regions of the brain such as the anterior olfactory nucleus, the piri-form cortex, the amygdaldoid complex, the entortinal cortex and the hippocampal may lead to the olfactory dysfunction 38 , 39 . However, correlation has also been suggested between the death of dopaminergic neurons and olfactory dysfunction 40 . Invertebrate brain though simpler but is capable of directing complex behaviors, learning and memory.…”
Section: Discussionmentioning
confidence: 99%
“…Post-mortem studies performed on PD patients revealed that due to the formation of Lewy bodies in the olfactory bulb and in other regions of the brain such as the anterior olfactory nucleus, the piri-form cortex, the amygdaldoid complex, the entortinal cortex and the hippocampal may lead to the olfactory dysfunction 38 , 39 . However, correlation has also been suggested between the death of dopaminergic neurons and olfactory dysfunction 40 . Invertebrate brain though simpler but is capable of directing complex behaviors, learning and memory.…”
Section: Discussionmentioning
confidence: 99%
“…51 Interestingly, genomewide location analysis of the NuA4/TIP60 complex in human K562 cells previously reported its presence on the PER1 and HDAC4 genes (see Figure S3). 7 Importantly, KAT5 has been shown to be critical for learning and memory in Drosophila [52][53][54] and has also been shown to control sleep in Drosophila by regulating axonal growth in pacemaker cells. 55 In addition, mammalian KAT5 has recently been reported to be an important regulator of the circadian clock cycle through direct action at gene promoters and BMAL1 acetylation.…”
Section: Discussionmentioning
confidence: 99%