Mating with seminal vesicle-excised male can affect the uterus phospholipid fatty-acids composition during implantation in an experimental mouse model

Fattahi, Amir; Latifi, Zeinab; Darabi, Masoud; Salmassi, Ali; Farzadi, Laya; Shaaker, Maghsood; Mehdizadeh, Amir; Ghasemnejad, Tohid; Roshangar, Leila; Nouri, Mohammad

doi:10.1590/s1677-5538.ibju.2018.0485

Cited by 2 publications

(2 citation statements)

References 22 publications

(28 reference statements)

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“…This increased pre-implantation mortality but decreased post-implantation losses. The influence of immune signals present in seminal fluid on the uterus and its preparation for embryo implantation has been shown in several studies [ 13 , 14 , 33 , 34 , 35 , 36 ]. In the seminal fluid, these immune signals could cause an increase in the number of leukocytes, appearance of antigen-specific immunoglobulins, changes in prostaglandins, cytokines levels, etc.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Sperm and Seminal Fluid of Immunized Male Mice on In Vitro Fertilization and Surrogate Mother–Embryo Interaction

Kontsevaya

Gerlinskaya

Moshkin

et al. 2021

IJMS

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The latest vaccination campaign has actualized the potential impact of antigenic stimuli on reproductive functions. To address this, we mimicked vaccination’s effects by administering keyhole limpet hemocyanin (KLH ) to CD1 male mice and used their sperm for in vitro fertilization (IVF). Two-cell embryos after IVF with spermatozoa from control (C) or KLH-treated (Im) male mice were transferred to surrogate mothers mated with vasectomized control (C) or KLH-treated (Im) male mice, resulting in four experimental groups: C–C, Im–C, C–Im, and Im–Im. The pre-implantation losses were significantly lower in the Im–C group than in the C–Im group. At the same time, the resorption rates reduced markedly in the C–Im compared to the Im–C group. Embryo and placenta weights were significantly higher in the Im–Im group. Although the GM-CSF levels were lower in the amniotic fluid of the gestating surrogate mothers in the Im–Im group, they were strongly correlated with embryo mass. The number–size trade-off was only significant in the Im–Im group. This suggests a positive, cooperative effect of spermatozoa and seminal fluid from immune-primed males on embryo growth and the optimal distribution of surrogate mother maternal resources despite the negative impact of males’ antigenic challenge on the IVF success rate.

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Section: Discussionmentioning

confidence: 99%

The Effects of Sperm and Seminal Fluid of Immunized Male Mice on In Vitro Fertilization and Surrogate Mother–Embryo Interaction

Kontsevaya

Gerlinskaya

Moshkin

et al. 2021

IJMS

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“…In mice, seminal fluid exposure induces a range of transcriptional changes in the endometrium [ 81 ], which may promote cross-talk between γδ T cells and ESCs. Other changes in the uterus occur after seminal fluid exposure, such as modified phospholipid content including altered levels of linoleic acid, arachidonic acid, saturated fatty acids, and polyunsaturated fatty acids [ 82 ]. Given that phospholipid-sensing is a feature of γδ T cells in humans and mice, its potential to activate or regulate γδ T cells in the uterus after insemination and across pregnancy should be investigated.…”

Section: Other Potential Functions Of γδ T Cells In Reproductionmentioning

confidence: 99%

Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success?

Foyle,

Robertson

2024

Discovery Immunology

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Summary The female reproductive tract accommodates and balances the unique immunological challenges of protection from sexually-transmitted pathogens and tolerance of the fetus and placenta in pregnancy. Leukocytes in the female reproductive tract actively engage in extensive maternal adaptations that are imperative for embryo implantation, placental development, and fetal support. γδ T cells are abundant at many mucosal sites in the body, where they provide protection against pathogens and cancer and have roles in tissue renewal and homeostasis. In this review we summarize studies in human and rodents showing that γδ T cells are prevalent in the female reproductive tract and fluctuate in response to hormone changes over the course of the cycle. Emerging evidence points to a link between changes in their abundance and molecular repertoire in the uterus and pregnancy disorders including recurrent miscarriage and preterm birth. However, defining the precise functional role of female reproductive tract γδ T cells and understanding their physiological significance in reproduction and pregnancy has remained elusive. Here, we critically analyze whether reproductive tract γδ T cells could be active participants in reproductive events - or alternatively whether their principal function is immune defense, in which case they may compromise pregnancy success unless adequately regulated.

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Mating with seminal vesicle-excised male can affect the uterus phospholipid fatty-acids composition during implantation in an experimental mouse model

Cited by 2 publications

References 22 publications

The Effects of Sperm and Seminal Fluid of Immunized Male Mice on In Vitro Fertilization and Surrogate Mother–Embryo Interaction

The Effects of Sperm and Seminal Fluid of Immunized Male Mice on In Vitro Fertilization and Surrogate Mother–Embryo Interaction

Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success?

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