MATN3 delivered by exosome from synovial mesenchymal stem cells relieves knee osteoarthritis: Evidence from in vitro and in vivo studies

Long, Long; Zou, Guoyou; Cheng, Yi; Li, Feng; Wu, Hao; Shen, Yixin

doi:10.1016/j.jot.2023.06.003

Cited by 10 publications

(4 citation statements)

References 54 publications

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“…This point notwithstanding, there is great interest in harnessing the potential of stem cells [ 44 ]. This includes utilizing them as cell based therapies or as similarly derived exosomes with signaling factors to halt the progression of degeneration and even potentially reverse it [ 45 , 46 , 47 , 48 , 49 , 50 ].…”

Section: Non-surgical Managementmentioning

confidence: 99%

Knee Joint Preservation in Tactical Athletes: A Comprehensive Approach Based upon Lesion Location and Restoration of the Osteochondral Unit

Cognetti,

Defoor,

Yuan

et al. 2024

Bioengineering

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The unique physical demands of tactical athletes put immense stress on the knee joint, making these individuals susceptible to injury. In order to ensure operational readiness, management options must restore and preserve the native architecture and minimize downtime, while optimizing functionality. Osteochondral lesions (OCL) of the knee have long been acknowledged as significant sources of knee pain and functional deficits. The management of OCL is predicated on certain injury characteristics, including lesion location and the extent of subchondral disease. Techniques such as marrow stimulation, allograft and autologous chondrocyte implantation are examined in detail, with a focus on their application and suitability in tactical athlete populations. Moreover, the restoration of the osteochondral unit (OCU) is highlighted as a central aspect of knee joint preservation. The discussion encompasses the biomechanical considerations and outcomes associated with various cartilage restoration techniques. Factors influencing procedure selection, including lesion size, location, and patient-specific variables, are thoroughly examined. Additionally, the review underscores the critical role of post-operative rehabilitation and conditioning programs in optimizing outcomes. Strengthening the surrounding musculature, enhancing joint stability, and refining movement patterns are paramount in facilitating the successful integration of preservation procedures. This narrative review aims to provide a comprehensive resource for surgeons, engineers, and sports medicine practitioners engaged in the care of tactical athletes and the field of cartilage restoration. The integration of advanced preservation techniques and tailored rehabilitation protocols offers a promising avenue for sustaining knee joint health and function in this demanding population.

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Section: Non-surgical Managementmentioning

confidence: 99%

Knee Joint Preservation in Tactical Athletes: A Comprehensive Approach Based upon Lesion Location and Restoration of the Osteochondral Unit

Cognetti,

Defoor,

Yuan

et al. 2024

Bioengineering

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“…Synovial MSC-derived exosomes with MATN3 improved OA scores in mice. Long et al identified that MATN3 interacted with IL-17A to prevent the activation of its downstream signaling (PI3K pathway) [160].…”

Section: Mesenchymal Stem-cell-derived Extracellular Vesicles and Cho...mentioning

confidence: 99%

The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis

Bakinowska,

Kiełbowski,

Pawlik

2023

Cells

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Cells can communicate with each other through extracellular vesicles (EVs), which are membrane-bound structures that transport proteins, lipids and nucleic acids. These structures have been found to mediate cellular differentiation and proliferation apoptosis, as well as inflammatory responses and senescence, among others. The cargo of these vesicles may include immunomodulatory molecules, which can then contribute to the pathogenesis of various diseases. By contrast, EVs secreted by mesenchymal stem cells (MSCs) have shown important immunosuppressive and regenerative properties. Moreover, EVs can be modified and used as drug carriers to precisely deliver therapeutic agents. In this review, we aim to summarize the current evidence on the roles of EVs in the progression and treatment of rheumatoid arthritis (RA) and osteoarthritis (OA), which are important and prevalent joint diseases with a significant global burden.

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“…Osteoarthritis (OA) is a common degenerative disease that is caused by various factors leading to articular cartilage degeneration and damage, with joint pain as the main symptom. − More than 250 million people worldwide suffer from OA, most of whom have decreased mobility and quality of life. , Conventional drug therapy is palliative, while it remains challenging to effectively promote cartilage regeneration and reverse the process of OA. − By contrast, stem cell-derived exosome (Exo) therapy, emerged from the perspective of regenerative medicine, has achieved preliminary success in OA treatment. − Moreover, previous studies have demonstrated that Exo can exert therapeutic effects in OA treatment by inhibiting inflammatory factors, preventing extracellular matrix extracellular matrix and promoting cartilage regeneration. − However, the scarcity of Exo and their complex isolation procedures pose great limitations for their applications . In addition, half-life of Exo in vivo is short, since they can be easily recognized by the mononuclear phagocyte system and rapidly cleared. − To address this problem, different Exo-delivered systems have been developed for OA treatment, such as nanoparticles, , liposomes, , and hydrogels. − These strategies can extend the half-life of Exo and many successes have been achieved.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Polysaccharide Mesenchymal Stem Cells Exosomes Delivery Microcarriers for Synergistic Therapy of Osteoarthritis

Yang,

Li,

Zhao

et al. 2024

ACS Nano

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Osteoarthritis (OA) is a prevalent degenerative disease that afflicts more than 250 million people worldwide, impairing their mobility and quality of life. However, conventional drug therapy is palliative. Exosomes (Exo), although with the potential to fundamentally repair cartilage, face challenges in their efficient enrichment and delivery. In this study, we developed magnetic polysaccharide hydrogel particles as microcarriers for synergistic therapy of OA. The microcarriers were composed of modified natural polysaccharides, hyaluronic acid (HAMA), and chondroitin sulfate (CSMA), and were generated from microfluidic electrospray in combination with a cryogelation process. Magnetic nanoparticles with spiny structures capable of capturing stem cell Exo were encapsulated within the microcarriers together with an anti-inflammatory drug diclofenac sodium (DS). The released DS and Exo from the microcarriers had a synergistic effect in alleviating the OA symptoms and promoting cartilage repair. The in vitro and in vivo results demonstrated the excellent performance of the microcarrier for OA treatment. We believe this work has potential for Exo therapy of OA and other related diseases.

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MATN3 delivered by exosome from synovial mesenchymal stem cells relieves knee osteoarthritis: Evidence from in vitro and in vivo studies

Cited by 10 publications

References 54 publications

Knee Joint Preservation in Tactical Athletes: A Comprehensive Approach Based upon Lesion Location and Restoration of the Osteochondral Unit

Knee Joint Preservation in Tactical Athletes: A Comprehensive Approach Based upon Lesion Location and Restoration of the Osteochondral Unit

The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis

Magnetic Polysaccharide Mesenchymal Stem Cells Exosomes Delivery Microcarriers for Synergistic Therapy of Osteoarthritis

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