Matrilysin Expression Related to Radiation and Microflora Changes in Murine Bowel

Polistena, Andrea; Johnson, Louis Banka; Röme, Andrada; Wittgren, Lena; Bäck, Sven; Osman, Nadia; Molin, Göran; Adawi, Diya; Jeppsson, Bengt

doi:10.1016/j.jss.2010.12.031

Cited by 4 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is seen in tissue repair and wound healing after inflammation, and after various types of injury and trauma (11,(34)(35)(36). In our clinical setting, there was a double factor potentially acting on ECM remodelling since RT alone or surgery alone, or both in combination, clearly affected MMP7 expression.…”

Section: Discussionmentioning

confidence: 81%

See 1 more Smart Citation

MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer

Stene

Polistena

Gaber

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 81%

“…In a murine model of radiation-induced enteropathy, both MMP7 and TGFβ were up-regulated by irradiation (11). RT has also been found to induce an elevation of MMP7 in humans (9,12).…”

mentioning

confidence: 93%

MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer

Stene

Polistena

Gaber

et al. 2018

View full text Add to dashboard Cite

show abstract

“…We showed a direct impact of antibody intervention at the early timepoints within two days postirradiation; but the resulting feedback upregulation of IL-17 in non-irradiated control mice at the time of three weeks after anti-IL-17 treatment suspected significantly reduced TGF-β by irradiation in mice with intestinal microbiota restriction. Increased TGF-β was measured in peripheral blood in RM and higher gene expression of proinflammatory cytokines in the small intestine in irradiated RM mice [2], along the lines of protected small intestinal crypt stem cells [24][25][26] or matrilysin expression [27]. Studies explored gain-in-function mutations for structural interactions among proteins of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family and TGF-β signaling genes to promote colorectal adenocarcinomas.…”

Section: Different Gut Microbiota Can Both Negatively and Positively ...mentioning

confidence: 99%

Radiation Impacts Microbiota Compositions That Activate Transforming Growth Factor-Beta Expression in the Small Intestine

Maier

2023

Microbiology Research

View full text Add to dashboard Cite

The composition of the gut microbiota represents an early indicator of chronic post-radiation outcomes in elderly bone and gastrointestinal homeostasis. Fecal microbiota analyses revealed that the relative abundances of Bacteroides massiliensis, Muribaculum sp., or Prevotella denticola were different between conventional microbiota (CM) and anti-inflammatory restricted microbiota (RM). The murine RM was found conditional on mucosa-associated dysbiosis under both, disturbances of interleukin (IL)-17 signaling and exposure to radiation alone. This review discusses the hypothesis that intestinal microbiota induced alterations in DNA repair and expressed transforming growth factor (TGF)-β in the small intestine, thereby impacting bone microstructure and osteoblast dysfunction in silicon ion (1.5 Gy 28Si ions of 850 MeV/u) irradiated mice. Bacterial microbiota compositions influenced therapeutic approaches, correlated with clinical outcomes in radiotherapy and were associated with alterations of the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections during the last global pandemics. In the absence of TGF-β, functional metagenomics, cytokine profiles, bacterial community analyses in human and murine mucosa cells, and inflammatory markers in rat intestines were analyzed. This research finally showed radiation-induced osteolytic damage to correlated with specific features of intestinal bacterial composition, and these relationships were expatiated together with radiation effects on normal tissue cell proliferation.

show abstract

Epigenetics in radiation-induced fibrosis

et al. 2014

View full text Add to dashboard Cite

Radiotherapy is a major cancer treatment option but dose-limiting side effects such as late-onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts to explain radiation-induced fibrosis, for example, by genetic variation remained largely inconclusive. Recently published molecular analyses on radiation response and fibrogenesis showed a prominent role of epigenetic gene regulation. This review summarizes the current knowledge on epigenetic modifications in fibrotic disease and radiation response, and it points out the important role for epigenetic mechanisms such as DNA methylation, microRNAs and histone modifications in the development of this disease. The synopsis illustrates the complexity of radiation-induced fibrosis and reveals the need for investigations to further unravel its molecular mechanisms. Importantly, epigenetic changes are long-term determinants of gene expression and can therefore support those mechanisms that induce and perpetuate fibrogenesis even in the absence of the initial damaging stimulus. Future work must comprise the interconnection of acute radiation response and long-lasting epigenetic effects in order to assess their role in late-onset radiation fibrosis. An improved understanding of the underlying biology is fundamental to better comprehend the origin of this disease and to improve both preventive and therapeutic strategies.

show abstract

Matrilysin Expression Related to Radiation and Microflora Changes in Murine Bowel

Cited by 4 publications

References 31 publications

MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer

MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer

Radiation Impacts Microbiota Compositions That Activate Transforming Growth Factor-Beta Expression in the Small Intestine

Epigenetics in radiation-induced fibrosis

Contact Info

Product

Resources

About