Matrine@chitosan-D-proline nanocapsules as antifouling agents with antibacterial properties and biofilm dispersibility in the marine environment

Abstract

Antifoulants are the most vital substances in antifouling coatings to prevent marine organisms from colonizing the undersea substrate surfaces. In addition to antibacterial performance, inhibition of biofilm formation is an important criterion for antifouling coatings. In this study, we synthesized pH-responsive matrine@chitosan-D-proline (Mat@CS-Pro) nanocapsules of about 280 nm with antibacterial properties and biofilm dispersibility. The prepared Mat@CS-Pro nanocapsules exhibited high-level antibacterial properties, reaching about 93, 88, and 96% for E. coli, S. aureus, and P. aeruginosa, respectively. Such nanocapsules can cause irreversible damage to bacteria and cause them to lose their intact cell structures. Moreover, Mat@CS-Pro nanocapsules also possessed outstanding dispersal biofilm performances, in which the biofilm thickness of E. coli, S. aureus, and P. aeruginosa was decreased by 33, 74, and 42%, respectively, after 3 days of incubation. Besides, the Mat@CS-Pro nanocapsules had remarkable pH-responsive properties. As the environmental pH became acidic, the nanocapsules swelled to about 475 nm and the released concentration could reach 28.5 ppm after immersion for 10 h but maintained a low releasing rate in pH 8 conditions.

Anti-Fouling and Anti-Biofilm Performance of Self-Polishing Waterborne Polyurethane with Gemini Quaternary Ammonium Salts

“…What is more, fouling-resistant or foul-release coatings cannot completely preclude the adhesion of microorganisms, and once adhesion occurs, microorganisms will multiply and eventually lead to the loss of anti-fouling function [ 18 , 19 ]. Therefore, coatings having the ability to resist fouling adhesion and kill fouling organisms are potential anti-fouling measures [ 20 , 21 , 22 ].…”

Novel Matrine Derivatives as Potential Larvicidal Agents against Aedes albopictus: Synthesis, Biological Evaluation, and Mechanistic Analysis

“…Matrine ( MA ), a quinolizidine alkaloid and an important natural product, is isolated from the plant species of the family Fabaceae, Sophora flavescens Aiton, Sophora tonkinensis Gagnep, Sophora alopecuroides L. [ 1 , 2 , 3 ]. MA and its analogs possess a variety of biological properties, such as anticancer activity, anti-inflammatory activity, insecticidal activity, antimicrobial activity, and antiviral activity; MA alkaloids are excellent precursors for structural modification and thus have attracted great interest from scholars [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. As an insecticide, MA has remarkable insecticidal activity against a variety of agricultural pests, such as Bradysia odoriphaga Yang et Zhang, Cnaphalocroci smedinalis (Guenee, 1854), Ectropis obliqua hypulina Wehrli, Clostera anachoreta Denis and Schiffermüller,1775, Eriosoma lanigerum (Hausmann), Psylla chinensis Yang et Li, Mesonura rufonota Rohwer, and Aceri macrodonis Keifer, with contact toxicity and gastric toxicity as the main modes of action [ 16 , 17 , 18 , 19 , 20 ].…”

Deciphering Alkaloid and Flavonoid Biosynthesis in Different Tissues of Sophora tonkinensis via Transcriptomics and Metabolomics

“…Notable alkaloids include large amounts of matrine and oxymatrine[4] and small amounts of sophocarpine, harmine, sophoranol, and sophoramol. Matrine and oxymatrine are recognized for their antibacterial, anti-in ammatory, and anti-cancer properties [5][6][7]. S. tonkinensis, aside from its roots and rhizomes, also yields matrine and oxymatrine from its aerial stems and leaves [1].…”