Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2

Wu, Li; Wang, Guizhen; Ji, Wei; Huang, Na; Zhang, Sen; Li, Ming; Wang, Lisheng

doi:10.18632/oncotarget.14329

Cited by 19 publications

(13 citation statements)

References 47 publications

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“…Our previous studies shown that matrine decreased the percentage of S phase cells, increased the percentage of cells in the G1 phase, accelerated the DNA synthesis process, increased DNA damage and genome instability . Other studies have shown that matrine can block cell cycle in G1 phase, S phase, or G2/M period . The observed synergistic impacts may be caused by either promoting the expression of GADD45B gene or through other signaling pathways such as EGFR/ERK/MMP‐2, AKT/GSK3β/β‐catenin, and PTEN/AKT to inhibit tumor cell progression .…”

Section: Discussionmentioning

confidence: 98%

Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B

Huang

Wang

et al. 2018

The Prostate

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Section: Discussionmentioning

confidence: 98%

Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B

Huang

Wang

et al. 2018

The Prostate

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“…Matrine exhibits a wide range of pharmacological effects and has long been applied to treat viral hepatitis (6), neuropathic pain (7), isoproterenol-induced cardiotoxicity inflammatory and other diseases (8,9). In addition, increasing evidence has revealed that matrine displays anticancer effects in various cancers, such as gastric (10), rhabdomyosarcoma (11), acute myeloid leukemia (12), osteosarcoma (13), prostate (14), breast (15) and lung cancer (16). Moreover, the antitumor mechanisms of matrine have been demonstrated to involve the blockade of cell cycle progression, the induction of apoptosis, the regulation of oncogene expression, the inhibition of cytokine production and the modulation of signaling pathways (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway

Zhou

Cai

2017

Oncology Reports

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Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found that matrine significantly inhibited cervical cancer cell growth by inducing apoptosis, and suppressed the invasion and migration ability of cervical cancer cells in vitro in a concentration-dependent manner. Mechanistically, we found that matrine decreased the expression and activity of the extracellular matrix factors, matrix metalloproteinases-2 (MMP-2) and MMP-9 via the suppression of p38 signaling pathway. In addition, when cervical cancer cells were grown as xenografts in nude mice, intraperitoneal (i.p.) injection of matrine induced a signiﬁcant dose-dependent decrease in tumor growth. Taken together, these findings suggest that a potential mechanism by which matrine inhibits the growth and metastasis of cervical cancer through downregulating the p38 signaling pathway.

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“…46 Recently, matrine derivative YF-18 inhibited lung cancer cell proliferation and migration through downregulation of Skp2. 47 Here, we validated NC as a new Skp2 inhibitor in ovarian cancer cells. Without a doubt, further investigation is required to explore whether NC exerts its tumor suppressive activity via inactivation of Skp2 in animal models.…”

Section: Discussionmentioning

confidence: 99%

Nitidine chloride inhibited the expression of S phase kinase-associated protein 2 in ovarian cancer cells

Mou

Guo

et al. 2017

Cell Cycle

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Nitidine chloride (NC) has been reported to exert its anti-tumor activity in various types of human cancers. However, the molecular mechanism of NC-mediated tumor suppressive function is largely unclear. In the current study, we used several approaches such as MTT, FACS, RT-PCR, Western blotting analysis, invasion assay, transfection, to explore the molecular basis of NC-triggered anti-cancer activity. We found that NC inhibited cell growth, induced cell apoptosis, caused cell cycle arrest in ovarian cancer cells. Emerging evidence has demonstrated that Skp2 plays an important oncogenic role in ovarian cancer. Therefore, we also explored whether NC exerts its biologic function via downregulation of Skp2 in ovarian cancer cells. We observed that NC significantly inhibited the expression of Skp2 in ovarian cancer cells. Notably, overexpression of Skp2 abrogated the anti-cancer activity induced by NC in ovarian cancer cells. Consistently, downregulation of Skp2 expression enhanced the sensitivity of ovarian cancer cells to NC treatment. Thus, inactivation of Skp2 by NC could be a novel strategy for the treatment of human ovarian cancer.

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Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2

Cited by 19 publications

References 47 publications

Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B

Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B

Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway

Nitidine chloride inhibited the expression of S phase kinase-associated protein 2 in ovarian cancer cells

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