Matrine-induced nephrotoxicity via GSK-3β/nrf2-mediated mitochondria-dependent apoptosis

Wang, Tianyang; Zhang, Jian; Wei, Haokai; Wang, Xi; Xie, Minjuan; Jiang, Yinjie; Zhou, Jie

doi:10.1016/j.cbi.2023.110492

Cited by 15 publications

(2 citation statements)

References 44 publications

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“…Matrine is an alkaloid extracted and isolated from the dried roots of Sophora flavescens Aiton. It exhibits a wide range of biological activities, such as antioxidant, anti-tumor, anti-inflammatory, anti-fibrotic, anti-arrhythmic, and immunomodulatory effects ( Wang et al, 2023 ). In an AGEs-induced SD rat model, matrine (50, 100, and 200 mg/kg/d) treatment for 20 days was found to inhibit the dissociation of FKBP12.6 and RyR2, reduce RyR2 activity and Ca 2+ levels, decrease the expression levels of cytochrome c and active Caspase3, suppress cell apoptosis, and restore Δψm ( Wang et al, 2019 ).…”

Section: Plant Secondary Metabolites-based Diabetes Cardiomyopathy Ta...mentioning

confidence: 99%

Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites

Pan,

Hao,

Zhang

et al. 2024

Front. Pharmacol.

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Diabetic cardiomyopathy (DCM) is a specific heart condition in diabetic patients, which is a major cause of heart failure and significantly affects quality of life. DCM is manifested as abnormal cardiac structure and function in the absence of ischaemic or hypertensive heart disease in individuals with diabetes. Although the development of DCM involves multiple pathological mechanisms, mitochondrial dysfunction is considered to play a crucial role. The regulatory mechanisms of mitochondrial dysfunction mainly include mitochondrial dynamics, oxidative stress, calcium handling, uncoupling, biogenesis, mitophagy, and insulin signaling. Targeting mitochondrial function in the treatment of DCM has attracted increasing attention. Studies have shown that plant secondary metabolites contribute to improving mitochondrial function and alleviating the development of DCM. This review outlines the role of mitochondrial dysfunction in the pathogenesis of DCM and discusses the regulatory mechanism for mitochondrial dysfunction. In addition, it also summarizes treatment strategies based on plant secondary metabolites. These strategies targeting the treatment of mitochondrial dysfunction may help prevent and treat DCM.

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Section: Plant Secondary Metabolites-based Diabetes Cardiomyopathy Ta...mentioning

confidence: 99%

Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites

Pan,

Hao,

Zhang

et al. 2024

Front. Pharmacol.

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“…Sophora flavescens has been reported to clear heat and remove dampness, which has antibacterial and anti-inflammatory effects [4]. OMT, as one of the major bioactive components in Sophora flavescens, has a wide range of pharmacological and biological activities [5], including antibacterial [6], antiviral, antioxidant, anti-tumor [7], and other effects [8].…”

Section: Introductionmentioning

confidence: 99%

Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells

Cao

Mao

et al. 2023

Molecules

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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic immunity and autoimmune disorders. We have previously found that oxymatrine (OMT), a natural alkaloid, can alleviate rheumatoid arthritis without knowing whether OMT can alleviate rheumatoid arthritis through gut microbiota. In this study, we found that OMT can alleviate collagen-induced arthritis in mice and reconstruct the immune balance of Th1/Th2, Treg/Th17, and Tfr/Tfh cells. Colon transcriptome gene enrichment analysis indicated that oxymatrine may alleviate collagen induced arthritis in mice through immune system process pathway. Furthermore, OMT significantly altered the gut microbiota variety, changed the composition of microbial colonies, and reshaped the gut microbiota of collagen-induced arthritis (CIA) mice, which may participate in the regulation of the balance of Th1/Th2, Treg/Th17, and Tfr/Tfh cells to alleviate collagen-induced arthritis in mice.

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The role and mechanism of β-catenin-mediated skeletal muscle satellite cells in osteoporotic fractures by Jian-Pi-Bu-Shen formula

Tang,

Mu,

Pan

et al. 2024

J Mol Histol

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Matrine-induced nephrotoxicity via GSK-3β/nrf2-mediated mitochondria-dependent apoptosis

Cited by 15 publications

References 44 publications

Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites

Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites

Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells

The role and mechanism of β-catenin-mediated skeletal muscle satellite cells in osteoporotic fractures by Jian-Pi-Bu-Shen formula

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