Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation

Xu, Panling; Cheng, Chien-Shan; Jiao, Juying; Chen, Hao; Chen, Zhen; Li, Ping

doi:10.1016/j.jep.2021.114691

Cited by 6 publications

(2 citation statements)

References 54 publications

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“…In ovarian cancer, matrine promotes apoptosis of cancer cells and increases the expression levels of p38MAPK, phosphorylated ERK/ ERK, and phosphorylated JNK/JNK (Liang & Ju, 2021). It is found that matrine inhibits the growth and induces apoptosis of pancreatic cancer cells (Xu et al, 2022). Matrine can promote the autophagy of cervical cancer cells through the Akt/mTOR signaling pathway and can be used as an autophagy inducer of cervical cancer (Zhang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Matrine exerts an anti‐tumor effect via regulating HN1 in triple breast cancer both in vitro and in vivo

Guo,

Yu,

Tang

et al. 2023

Chem Biol Drug Des

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The treatment of triple‐negative breast cancer (TNBC) cannot meet medical needs, and it is urgent to find new drugs for intervention. This study aimed to investigate the anti‐tumor effect of matrine on the proliferation and apoptosis of TNBC cells based on HN1 regulation in vitro and in vivo. TNBC cell lines (MDA‐MB‐453 and HCC‐1806) were treated with varying concentrations of matrine (0, 1.0, 2.0, 3.0, 4.0, and 5.0 mM). CCK‐8, colony formation assay, transwell assay, and flow cytometry assay were employed to detect proliferation, clone formation, invasion, and apoptosis of TNBC cells. Western blot analysis was applied to detect the protein expression of apoptosis HN1. The effects of matrine on tumor growth, protein expression of HN1, and apoptosis in vivo were validated by xenograft tumor models and histology. It was found that matrine inhibited proliferation, colony formation, and invasion and promoted apoptosis of TNBC cells in vitro. HN1 expression was suppressed by matrine. HN1 overexpression perceptibly reversed the above‐mentioned additive effect in vitro. In vivo experiments found that matrine inhibited tumor growth and the expression of HN1 protein but promoted the protein expression of Cleared‐Caspase‐3. Above all, this study demonstrated that matrine inhibited proliferation and promoted apoptosis of TNBC cells via suppressing HN1 expression. Targeting HN1 by matrine may provide new insights into the therapeutic management of patients with TNBC.

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Section: Discussionmentioning

confidence: 99%

Matrine exerts an anti‐tumor effect via regulating HN1 in triple breast cancer both in vitro and in vivo

Guo,

Yu,

Tang

et al. 2023

Chem Biol Drug Des

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“…It is an active alkaloid widely found in leguminous plants ( Zhang M W et al, 2023 ). It has extensive pharmacological effects, including antiviral, anti-inflammatory, anti-fibrosis, and anti-tumor activities ( Xu et al, 2022 ). Matrine can play an anti-pancreatic cancer effect through various mechanisms: ①Inducing apoptosis by reducing the Bcl-2/BAX ratio, upregulating Fas, and increasing activation of caspases-8, -3 and -9, inhibiting mitochondrial energy production ( Liu, T.Y., et al, 2010 ; Cho et al, 2018 ); ②Inhibiting pancreatic cancer cell migration and invasion through the ROS/NF-κB/MMPs pathway ( Huang and Xin, 2018 ); ③ Inhibiting HPAC cellular migration and invasion through down-regulating the expression of MT1-MMP via the Wnt signaling pathway ( Ma, Y.C., et al, 2015 ).…”

Section: Treatment With Chinese Herbsmentioning

confidence: 99%

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Zhang,

Xu,

et al. 2023

Front. Pharmacol.

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Pancreatic cancer is a common malignancy of the digestive system. With a high degree of malignancy and poor prognosis, it is called the “king of cancers.” Currently, Western medicine treats pancreatic cancer mainly by surgical resection, radiotherapy, and chemotherapy. However, the curative effect is not satisfactory. The application of Traditional Chinese Medicine (TCM) in the treatment of pancreatic cancer has many advantages and is becoming an important facet of comprehensive clinical treatment. In this paper, we review current therapeutic approaches for pancreatic cancer. We also review the protective effects shown by TCM in different models and discuss the potential molecular mechanisms of these.

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Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis

Wang,

Zhu,

Xing

et al. 2023

Chemico-Biological Interactions

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Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation

Cited by 6 publications

References 54 publications

Matrine exerts an anti‐tumor effect via regulating HN1 in triple breast cancer both in vitro and in vivo

Matrine exerts an anti‐tumor effect via regulating HN1 in triple breast cancer both in vitro and in vivo

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis

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