Matrine pre-treatment suppresses AGEs- induced HCSMCs fibrotic responses by regulating Poldip2/mTOR pathway

Ma, Wangxia; Xu, Jing; Zhang, Yong; Zhao, Hong; Zhu, Zhou; Zhou, Liqin; Wang, Xincheng; Liu, Hongbo; Chen, Yani; Du, Peng; Min, Ningbin; Liu, Zhongwei; Yin, Yanrong

doi:10.1016/j.ejphar.2019.172746

Cited by 15 publications

(7 citation statements)

References 13 publications

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“…Advanced glycosylation end products (AGEs) are a group of substances existing in poorly controlled type 2 diabetes mellitus, which promote the fibrotic response of VSMCs and then aggravate AS through mTOR signaling pathway activation (de Vos et al, 2016). Matrine pretreatment reduced the expression of PI3K and the phosphorylation of mTOR in a concentration-dependent manner, as well as inhibited AGEs-induced fibrosis response in human coronary smooth muscle cells (HCSMCs) (Ma et al, 2019). The regulatory effect of matrine on mTOR provides a new idea for the treatment of type 2 diabetes-associated AS.…”

Section: Alkaloidsmentioning

confidence: 99%

Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atherosclerosis: A review

Liu

et al. 2023

Front. Pharmacol.

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Atherosclerosis (AS) is a chronic inflammatory disease that is a major cause of cardiovascular diseases (CVDs), including coronary artery disease, hypertension, myocardial infarction, and heart failure. Hence, the mechanisms of AS are still being explored. A growing compendium of evidence supports that the activity of the mechanistic/mammalian target of rapamycin (mTOR) is highly correlated with the risk of AS. The mTOR signaling pathway contributes to AS progression by regulating autophagy, cell senescence, immune response, and lipid metabolism. Various botanical drugs and their functional compounds have been found to exert anti- AS effects by modulating the activity of the mTOR signaling pathway. In this review, we summarize the pathogenesis of AS based on the mTOR signaling pathway from the aspects of immune response, autophagy, cell senescence, and lipid metabolism, and comb the recent advances in natural compounds from botanical drugs to inhibit the mTOR signaling pathway and delay AS development. This review will provide a new perspective on the mechanisms and precision treatments of AS.

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Section: Alkaloidsmentioning

confidence: 99%

Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atherosclerosis: A review

Liu

et al. 2023

Front. Pharmacol.

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“…Matrine could down-regulate RyR2 expression, inhibit calcium overload caused by endoplasmic reticulum leakage to protect mitochondrial function, reduce age-induced heart injury and inhibit cardiomyocyte apoptosis (Wang et al, 2019a). Matrine could up-regulate poldip2 (polymerase δ Interacting protein2) expression, down-regulate Akt and mTOR phosphorylation, down-regulate phosphorylation level of downstream effector translation regulator P70S6K (70 kDa ribosomal S6 kinase), inhibit ECM protein expression, therefore, inhibit age-induced phenotypic transformation and fibrosis of HCMC (Ma et al, 2019).…”

Section: ) Anti-arrhythmia Activitymentioning

confidence: 99%

Research Advances on Matrine

et al. 2022

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Matrine is an alkaloid extracted from traditional Chinese herbs including Sophora flavescentis, Sophora alopecuroides, Sophora root, etc. It has the dual advantages of traditional Chinese herbs and chemotherapy drugs. It exhibits distinct benefits in preventing and improving chronic diseases such as cardiovascular disease and tumors. The review introduced recent research progresses on extraction, synthesis and derivatization of Matrine. The summary focused on the latest research advances of Matrine on anti-atherosclerosis, anti-hypertension, anti-ischemia reperfusion injury, anti-arrhythmia, anti-diabetic cardiovascular complications, anti-tumor, anti-inflammatory, anti-bacterium, anti-virus, which would provide new core structures and new insights for new drug development in related fields.

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“…Zhang et al 45 demonstrated that matrine effectively improved lipid metabolism, inflammation, and vascular wall thickness in mice fed a high-fat diet, reduced the phosphorylation of nitric oxide synthase 3 (ENOS)-Thr497, and increased the phosphorylation of ENOS-S1177, thereby resulted in an increase in NO production, which is mediated by PI3K/AKT and protein kinase C Alpha (PKCα), revealing the molecular mechanism underlying the protective effect of matrine in high-fat diet-induced vascular disease. Ma et al 46 pre-treated human coronary smooth muscle cells (HCSMCs) with matrine and then exposed them to advanced glycation end products (AGEs). They found that matrine pre-treatment significantly reduced collagen content, increased smooth muscle myosin heavy chain 11 (MYH11) and DNA polymerase delta interacting protein 2 (Poldip2) expression, decreased the expressions of collagen I, β1-integrin, PI3K and nuclear p-p70S6k, and reduced the phosphorylation of AKT and mTOR in HCSMCs exposed to AGEs.…”

Section: Matrine Exerts Pharmacological Effects Through the Pi3k/akt/...mentioning

confidence: 99%

Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review

Lin¹,

He²,

Wu³

et al. 2022

DDDT

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As The main effective monomer of the traditional Chinese medicine Sophora flavescens Ait , matrine has a broad scope of pharmacological activities such as anti-tumor, anti-inflammatory, analgesic, anti-fibrotic, anti-viral, anti-arrhythmia, and improving immune function. These actions explain its therapeutic effects in various types of tumors, cardiopathy, encephalomyelitis, allergic asthma, rheumatoid arthritis (RA), osteoporosis, and central nervous system (CNS) inflammation. Evidence has shown that the mechanism responsible for the pharmacological actions of matrine may be via the activation or inhibition of certain key molecules in several cellular signaling pathways including the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), transforming growth factor-β/mothers against decapentaplegic homolog (TGF-β/Smad), nuclear factor kappa B (NF-κB), Wnt (wingless/ integration 1)/β-catenin, mitogen-activated protein kinases (MAPKs), and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways. This review comprehensively summarizes recent studies on the pharmacological mechanisms of matrine to provide a theoretical basis for molecular targeted therapies and further development and utilization of matrine.

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Matrine pre-treatment suppresses AGEs- induced HCSMCs fibrotic responses by regulating Poldip2/mTOR pathway

Cited by 15 publications

References 13 publications

Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atherosclerosis: A review

Natural compounds from botanical drugs targeting mTOR signaling pathway as promising therapeutics for atherosclerosis: A review

Research Advances on Matrine

Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review

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