Matrix-assisted laser desorption/ionization of amphiphilic fullerene derivatives

Brown, Tracy; Clipston, Nigel L.; Simjee, Nafeesa; Luftmann, Heinrich; Hungerbühler, Hartmut; Drewello, Thomas

doi:10.1016/s1387-3806(01)00429-8

Cited by 58 publications

(53 citation statements)

References 37 publications

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“…This is in contrast to errors that may arise from functional group loss, which has been observed previously for functionalized amphiphilic fullerenes [13]. In this work, differences in laser power did not show significant differences in molecular mass distribution as would be expected if functional groups were being removed by the ablation process.…”

Section: Discussioncontrasting

confidence: 56%

“…The center is used to assure that the function is changing as little as possible over the entire width of the MMD; however, mathematically the choice is arbitrary. Thus: (13) where k 0 and Q are the first two coefficients in the Taylor's expansion. They are also functions of all the experimental conditions: the instrument parameters, the sample concentrations, and the sample preparation method.…”

Section: Calculating the Correction Factor For Each Oligomermentioning

confidence: 99%

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A general method for quantitative measurement of molecular mass distribution by mass spectrometry

Park

Wallace

Guttman

et al. 2009

J. Am. Soc. Mass Spectrom.

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A method is presented to test whether the conversion of the mass spectrum of a polydisperse analyte to its molecular mass distribution is quantitative. Mixtures of samples with different average molecular masses, coupled with a Taylor's expansion mathematical formalism, were used to ascertain the reliability of molecular mass distributions derived from mass spectra. Additionally, the method describes how the molecular mass distributions may be corrected if the degree of mass bias is within certain defined limits. This method was demonstrated on polydisperse samples of C 60 fullerenes functionalized with ethylpyrrolidine groups measured by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; however, it is applicable to any polydisperse analyte and mass spectrometric method as long as spectrum resolution allows individual oligomers to be identified. Mass spectra of the derivatized fullerenes taken in positive ion mode were shown to give an accurate measurement of the molecular mass distribution while those taken in negative ion mode were not. Differences in the mechanisms for ion formation are used to explain the discrepancy.Official

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Section: Discussioncontrasting

confidence: 56%

Section: Calculating the Correction Factor For Each Oligomermentioning

confidence: 99%

A general method for quantitative measurement of molecular mass distribution by mass spectrometry

Park

Wallace

Guttman

et al. 2009

J. Am. Soc. Mass Spectrom.

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“…DCTB (trans-2-[3-{4-tert-Butylphenyl}-2-methyl-2-propenylidene]malononitrile, whose structure is shown in Figure 1c) was supplied by Fluka (Buchs, Switzerland) and used as the matrix. DCTB was recently introduced as a matrix material for MALDI with derivatized fullerenes [15] and comprehensive screening experiments including some fourteen common matrices revealed DCTB as the best performing matrix for this purpose [16]. DCTB was dissolved in toluene at a concentration of 1 mg per ml.…”

Section: Sample Preparationmentioning

confidence: 99%

“…DCTB was dissolved in toluene at a concentration of 1 mg per ml. Both analyte and matrix solution were freshly prepared and combined to a molar matrix-to-analyte ratio of 1000:1 [16]. To produce the salt layers, the alkali halides (Sigma Aldrich, Gillingham-Dorset, UK, 99.9% purity) were dissolved in methanol as 0.001 molar solutions (for solubility see [22]).…”

Section: Sample Preparationmentioning

confidence: 99%

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Alkali cation attachment to derivatized fullerenes studied by matrix-assisted laser desorption/ionization

Fati

Leeman

Vasil’ev

et al. 2002

J. Am. Soc. Mass Spectrom.

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The complexation of alkali metal ions with amphiphilic fullerene derivatives has been investigated by matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry. The formation of analyte ions occurs via two competing mechanisms including electron transfer from matrix-derived ions and metal ion attachment. The interplay of these processes has been examined by laser fluence dependent sample activation and by variation of the target composition. The attachment of metal ions has been established as the gentler and thus more efficient route towards the formation of intact analyte ions. Investigations into the metal ion complexation have been conducted to reveal the reactivity order of the alkali metals in these reactions and to elucidate the influence of structural differences of the analytes, as well as to unravel effects caused by the anionic counter ion of the metal. The experimental data have been derived by two complementary approaches. Competing reactants were either studied simultaneously, so that the product distribution would provide direct insight into the reactivity pattern, and/or product distributions were obtained in a large variety of separate experiments and normalized for reliable comparison. It has been found that the extent to which complexation is observed follows the charge density order of the alkali metal ions. The structural features of the fullerene-attached ligands were of profound influence on the attachment of the metal ion, inducing enhanced selectivity for the complexation with less reactive metals. The metal ion attachment is reduced with the use of smaller anionic counter ions. Rationalization of these findings is provided within the framework of the mechanisms of ion formation in

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MALDI Ionization Mechanisms: An Overview

Knochenmuss¹

2010

Electrospray and MALDI Mass Spectrometry

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Matrix-assisted laser desorption/ionization of amphiphilic fullerene derivatives

Cited by 58 publications

References 37 publications

A general method for quantitative measurement of molecular mass distribution by mass spectrometry

A general method for quantitative measurement of molecular mass distribution by mass spectrometry

Alkali cation attachment to derivatized fullerenes studied by matrix-assisted laser desorption/ionization

MALDI Ionization Mechanisms: An Overview

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