2011
DOI: 10.1016/j.forsciint.2010.08.010
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Matrix-assisted laser desorption/ionization–time of flight-mass spectrometry profiling of trace constituents of condom lubricants in the presence of biological fluids

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Cited by 48 publications
(34 citation statements)
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“…This class of agents can be applied directly on injured skin and ulcerated surfaces, where they remain localized for long periods of time to produce a prolonged anaesthetic action. Benzocaine is incorporated into a large number of topical preparations [11] for local anaesthesia, such as dental sprays, ear medication or in throat anaesthetic lozenges [13] and as a desensitizer in condoms [14]. …”
Section: Introductionmentioning
confidence: 99%
“…This class of agents can be applied directly on injured skin and ulcerated surfaces, where they remain localized for long periods of time to produce a prolonged anaesthetic action. Benzocaine is incorporated into a large number of topical preparations [11] for local anaesthesia, such as dental sprays, ear medication or in throat anaesthetic lozenges [13] and as a desensitizer in condoms [14]. …”
Section: Introductionmentioning
confidence: 99%
“…Although nonoxynol-9 has been incorrectly presented as having an unbranched nonyl side chain [4,13], the chromatograms shown herein illustrate its inherent complexity. In total, both of the substituents branching off the core phenol structure of nonoxynol-9 are variable, making the overall "structure" an even more convoluted "mixture of mixtures," best described as the generic chemical structure in Figure 1.…”
Section: Resultsmentioning
confidence: 86%
“…Consequently, the most illustrative mass spectral data of nonoxynol-9 to date have been obtained by LC-MS and desorption chemical ionization MS, which yielded chromatograms in which the individual isomeric components were not resolved [4,5]. These techniques employ softer ionization methods that produce primarily molecular ions and simpler spectra with little to no fragmentation when compared with EI-based methods [6,[10][11][12][13]. The incorporation of a simple sonication step during the extraction was designed to disrupt micelles to better solubilize the material.…”
Section: Resultsmentioning
confidence: 99%
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“…Extraction of the condom-related traces can be carried out with dichloromethane, followed by drying and re-solubilisation with methanol. Suitable matrices are 2,5-dihydroxybenzoic acid [123], dithranol in acetonitrile/dichloromethane/tetrahydrofuran (45:45:15 v/v) [124] and 2,5-dihydroxybenzoic acid and sodium chloride (75 mg/mL in acetone) [125]. Lubricants, additives and spermicides can be detected by this approach.…”
Section: Characterisation Of Other Additivesmentioning
confidence: 99%