Matrix-Assisted Pulsed laser Evaporation-deposited Rapamycin Thin Films Maintain Antiproliferative Activity

Cristescu, R.; Neguț, Irina; Visan, Anita Ioana; Nguyen, Alexander K.; Sachan, Andrew; Goering, Peter L.; Chrisey, Douglas B.; Narayan, Roger J.

doi:10.18063/ijb.v6i1.188

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Laser-assisted techniques, such as Laser Induced Forward Transfer (LIFT) and stereolithography (SLA), have been successfully used for fabricating two-dimensional microstructures with various geometries that could be used to influence cell bio-dynamics (e.g., cells attachment, cells proliferation, etc.) [57,58]. However, these structures have shown several limitations, the most important being reduced cell viability and the lack of 3D inter-cellular connections similar to living tissues, which determined the formation of unwanted necrotic cores [3].…”

Section: Laser Assisted Fabrication Methodsmentioning

confidence: 99%

A Review on Stimuli-Actuated 3D Micro/Nanostructures for Tissue Engineering and the Potential of Laser-Direct Writing via Two-Photon Polymerization for Structure Fabrication

Călin

Păun

2022

IJMS

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In this review, we present the most recent and relevant research that has been done regarding the fabrication of 3D micro/nanostructures for tissue engineering applications. First, we make an overview of 3D micro/nanostructures that act as backbone constructs where the seeded cells can attach, proliferate and differentiate towards the formation of new tissue. Then, we describe the fabrication of 3D micro/nanostructures that are able to control the cellular processes leading to faster tissue regeneration, by actuation using topographical, mechanical, chemical, electric or magnetic stimuli. An in-depth analysis of the actuation of the 3D micro/nanostructures using each of the above-mentioned stimuli for controlling the behavior of the seeded cells is provided. For each type of stimulus, a particular recent application is presented and discussed, such as controlling the cell proliferation and avoiding the formation of a necrotic core (topographic stimulation), controlling the cell adhesion (nanostructuring), supporting the cell differentiation via nuclei deformation (mechanical stimulation), improving the osteogenesis (chemical and magnetic stimulation), controlled drug-delivery systems (electric stimulation) and fastening tissue formation (magnetic stimulation). The existing techniques used for the fabrication of such stimuli-actuated 3D micro/nanostructures, are briefly summarized. Special attention is dedicated to structures’ fabrication using laser-assisted technologies. The performances of stimuli-actuated 3D micro/nanostructures fabricated by laser-direct writing via two-photon polymerization are particularly emphasized.

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Section: Laser Assisted Fabrication Methodsmentioning

confidence: 99%

A Review on Stimuli-Actuated 3D Micro/Nanostructures for Tissue Engineering and the Potential of Laser-Direct Writing via Two-Photon Polymerization for Structure Fabrication

Călin

Păun

2022

IJMS

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“…Rodica Cristescu et al [97] demonstrated that matrix-assisted pulsed laser evaporation (MAPLE) has many benefits compared with conventional methods (e.g., dip-coating, spin coating, and Langmuir-Blodgett dip-coating) for manufacturing coatings containing pharmacologic agents on medical devices. As a particularity of this technique, the thickness of the coating that is applied to the surface of the medical device can be tightly controlled.…”

Section: Coated Microneedles Have Two Principal Functionsmentioning

confidence: 99%

Polymeric Coatings for Drug Delivery by Medical Devices

Anghel

Mahmood

Matei

et al. 2021

J. Nanotech. Diagn. Treat.

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An analysis of the current landscape of therapeutics and delivery methods was conducted, aiming the field of drug delivery systems. Drug delivery biodistribution characteristics should be systematically understood, in order to maximize the function of these delivery systems. As a result, this review covers a history of the drug delivery systems, as well as the basic terminology associated with them, with a focus on the usage of polymers in the drug administration systems (particularly in form of coatings) and their application. New trends in nanomaterials-based drug delivery systems, primarily for cancer treatment, were presented, involving a technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. There is a justified need to investigate drug delivery systems in form of thin films because, in comparation to bulk drug delivery system, which have a long and comprehensive history, there is still insufficient and fragmented understanding about the delivery of thin polymeric films, with research limited in general to very specific cases. Our efforts have been concentrated on these specifically polymeric drug delivery systems in the form of coatings. Understanding the dynamic changes that occur in a biodegradable polymeric thin film can aid in the prediction of the future performance of synthesized films designed to be used as implantable medical devices. Extensive research is required to continuously develop new therapeutic systems in order to achieve an optimal concentration of a specific drug at its site of action for an appropriate duration.

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“…MAPLE uses laser energy to transfer thin films of different materials while maintaining the original characteristics of the material [ 15 ]. MAPLE deposition technique offers a high degree of control over the deposited particles’ size, shape, and orientation, which is critical for many advanced applications [ 16 , 17 , 18 ]. By adjusting the laser energy and duration, the thickness and composition of the deposited film can also be controlled precisely.…”

Section: Introductionmentioning

confidence: 99%

In-Depth Characterization of Two Bioactive Coatings Obtained Using MAPLE on TiTaZrAg

Prodana,

Stoian,

Ionita

et al. 2024

Materials

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TiZrTaAg alloy is a remarkable material with exceptional properties, making it a unique choice among various industrial applications. In the present study, two types of bioactive coatings using MAPLE were obtained on a TiZrTaAg substrate. The base coating consisted in a mixture of chitosan and bioglass in which zinc oxide and graphene oxide were added. The samples were characterized in-depth through a varied choice of methods to provide a more complete picture of the two types of bioactive coating. The analysis included Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), ellipsometry, and micro-Raman. The Vickers hardness test was used to determine the hardness of the films and the penetration depth. Film adhesion forces were determined using atomic force microscopy (AFM). The corrosion rate was highlighted by polarization curves and by using electrochemical impedance spectroscopy (EIS). The performed tests revealed that the composite coatings improve the properties of the TiZrTaAg alloy, making them feasible for future use as scaffold materials or in implantology.

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Matrix-Assisted Pulsed laser Evaporation-deposited Rapamycin Thin Films Maintain Antiproliferative Activity

Cited by 5 publications

References 22 publications

A Review on Stimuli-Actuated 3D Micro/Nanostructures for Tissue Engineering and the Potential of Laser-Direct Writing via Two-Photon Polymerization for Structure Fabrication

A Review on Stimuli-Actuated 3D Micro/Nanostructures for Tissue Engineering and the Potential of Laser-Direct Writing via Two-Photon Polymerization for Structure Fabrication

Polymeric Coatings for Drug Delivery by Medical Devices

In-Depth Characterization of Two Bioactive Coatings Obtained Using MAPLE on TiTaZrAg

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