Matrix assisted pulsed laser evaporation of cinnamate-pullulan and tosylate-pullulan polysaccharide derivative thin films for pharmaceutical applications

Jelínek, M.; Cristescu, R.; Axente, E.; Kocourek, T.; Dybal, Jiřı́; Remsa, Jan; Pleštil, Josef; Mihăiescu, Dan Eduard; Albulescu, M.; Buruiană, Tinca; Stamatin, I.; Mihăilescu, I. N.; Chrisey, Douglas B.

doi:10.1016/j.apsusc.2007.02.085

Cited by 17 publications

(6 citation statements)

References 12 publications

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“…PLLN is known to be a mucoadhesive polymer (28,29) and may impart bioadhesion to the matrix. The energy minimizations were found to be a collective phenomenon including nonbonding interactions in the form of van der Waals forces, H bonding and electrostatic interactions (Eqs.…”

mentioning

confidence: 99%

Design of an Interpolyelectrolyte Gastroretentive Matrix for the Site-Specific Zero-Order Delivery of Levodopa in Parkinson’s Disease

et al. 2013

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Abstract. This study focused on developing a gastroretentive drug delivery system employing a triplemechanism interpolyelectrolyte complex (IPEC) matrix comprising high density, swelling, and bioadhesiveness for the enhanced site-specific zero-order delivery of levodopa in Parkinson's disease. An IPEC was synthesized and directly compressed into a levodopa-loaded matrix employing pharmaceutical technology and evaluated with respect to its physicochemical and physicomechanical properties and in vitro drug release. The IPEC-based matrix displayed superior mechanical properties in terms of matrix hardness (34-39 N/mm) and matrix resilience (44-47%) when different normality's of solvent and blending ratios were employed. Fourier transform infrared spectroscopy confirmed the formation of the IPEC. The formulations exhibited pH and density dependence with desirable gastro-adhesion with Peak Force of Adhesion ranging between 0.15 and 0.21 N/mm, densities from 1.43 to 1.54 g/cm 3 and swellability values of 177-234%. The IPEC-based gastroretentive matrix was capable of providing site-specific levodopa release with zero-order kinetics corroborated by detailed mathematical and molecular modeling studies. Overall, results from this study have shown that the IPEC-based matrix has the potential to improve the absorption and subsequent bioavailability of narrow absorption window drugs, such as levodopa with constant and sustained drug delivery.

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confidence: 99%

Design of an Interpolyelectrolyte Gastroretentive Matrix for the Site-Specific Zero-Order Delivery of Levodopa in Parkinson’s Disease

et al. 2013

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“…Furthermore, the intensity of the bands corresponding to the maghemite γ-Fe 2 O 3 phase increases with increasing NPs concentration in the composite targets used in MAPLE experiments. The typical surface morphology of thin films deposited by MAPLE technique is characterized by an aggregated structure, consisting of micrometer-sized particles [17,18,22,39,119]. It is worth noting that a larger specific surface area was proven to induce an enhanced bioactivity, able to promote osteoblast differentiation, as reported in case of hybrid organic-inorganic thin films deposited by MAPLE [120,121].…”

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 76%

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Axente¹,

Sima²,

Ristoscu³

et al. 2016

Recent Advances in Biopolymers

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This chapter provides an overview of recent advances in the field of laser-based synthesis of biopolymer thin films for biomedical applications. The introduction addresses the importance of biopolymer thin films with respect to several applications like tissue engineering, cell instructive environments, and drug delivery systems. The next section is devoted to applications of the fabrication of organic and hybrid organic-inorganic coatings. Matrix-assisted pulsed laser evaporation (MAPLE) and Combinatorial-MAPLE are introduced and compared with other conventional methods of thin films assembling on solid substrates. Advantages and limitations of the methods are pointed out by focusing on the delicate transfer of bio-macromolecules, preservation of properties and on the prospect of combinatorial libraries' synthesis in a single-step process. The following section provides a brief description of fundamental processes involved in the molecular transfer of delicate materials by MAPLE. Then, the chapter focuses on the laser synthesis of two polysaccharide thin films, namely Dextran doped with iron oxide nanoparticles and Levan, followed by an overview on the MAPLE synthesis of other biopolymers. The chapter ends with summary and perspectives of this fast-expanding research field, and a rich bibliographic database.

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“…Furthermore, thin films of pullulan, which are biodegradable, biocompatible, and with good mechanical properties, can be synthetized and used in various biomedical applications [33]. One processing method is MAPLE technique that allows for the deposition of high-quality pullulan films, e.g., triacetate-pullulan, cinnamate-pullulan and tosylate-pullulan [35,37,38].…”

Section: Pullulanmentioning

confidence: 99%

Protected Laser Evaporation/Ablation and Deposition of Organic/Biological Materials: Thin Films Deposition for Nano- biomedical Applications

Popescu-Pelin¹,

Ristoscu²,

Badiceanu³

et al. 2017

Laser Ablation - From Fundamentals to Applications

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This chapter reviews the laser ablation of delicate organic/biological substances by matrix-assisted pulsed laser evaporation (MAPLE). It is shown that direct ablation in this case is possible but sometimes not workable at all in adverse conditions. The considered solution is the protection by a prevalent dissolving/suspending component that can allow for a "shielded" ablation by the frozen solvent followed by its gradual evaporation by melting, evaporation and evacuation by pumping system. We extend the study to the case of non-UV absorbing solvents, e.g., water, when the primary interaction between laser and solute ignites evaporation process at a lower ablation threshold due to reduced pressure inside irradiation chamber. We called this case as "generalized" MAPLE interaction. Relevant examples are provided and critically analyzed in view of potential applications for nanobiomedicine, biosensors, advanced implants and chemical technologies.

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Matrix assisted pulsed laser evaporation of cinnamate-pullulan and tosylate-pullulan polysaccharide derivative thin films for pharmaceutical applications

Cited by 17 publications

References 12 publications

Design of an Interpolyelectrolyte Gastroretentive Matrix for the Site-Specific Zero-Order Delivery of Levodopa in Parkinson’s Disease

Design of an Interpolyelectrolyte Gastroretentive Matrix for the Site-Specific Zero-Order Delivery of Levodopa in Parkinson’s Disease

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Protected Laser Evaporation/Ablation and Deposition of Organic/Biological Materials: Thin Films Deposition for Nano- biomedical Applications

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