This paper is concerned with an investigation of the quantum mechanical dynamics of massive, spinless relativistic Klein-Gordon particle in the space-time generated by a rotating cosmic string. The equations of motion are found by the use of the first-order Feshbach-Villars formulation of the Klein-Gordon equation. The wave-functions and the associated energies were deduced ( both in the free and in the interaction case). Following that, the partition function was approximated using Zeta function representation. Moreover, by considering the energy spectrum of the system in question, the thermal properties are presented. We examine the behavior of these properties as a function of the physical parameters of the model such as rotation, curvature, and quantum numbers. Therefore, the impact of the topological defect on the quantum system under investigation is discussed.