In complex network analysis it is essential to investigate the alteration of network structures that results from the targeted removal of vertices or edges, ranked by centrality measures. Unfortunately, a sequential recalculation of centralities after each node elimination is often impractical for large networks, and computing rankings only at the beginning often does not accurately reflect the actual scenario. Here we propose a first result on the computational complexity of the sequential approach when nodes are removed from a network according to some centrality measures based on matrix functions. Moreover, we present two strategies that aim to reduce the computational impact of the sequential computation of centralities and provide theoretical results in support. Finally, we provide an application of our claims to the robustness of some synthetic and real-world networks.